N-hydroxyurea derivatives which inhibit lipoxygenase

Details N-hydroxyurea derivatives which inhibit lipoxygenase N-hydroxyurea derivatives which inhibit lipoxygenase

1993-12-10

1995-01-24

Ramsuer, Robert W.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

514429, 544168, 548577, A61K 31535, A61K 3140, C07D295155

Patent

active

053843207

ABSTRACT:
Compounds of the formula ##STR1## wherein X is --CH.sub.2 --, --O-- or --S--, m is 1 to 3, n is 1 or 2 and R.sub.1 is hydrogen, C.sub.1 to C.sub.4 alkyl, aryl or aryl substituted with one or more substituents selected independently from the group consisting of halogen, nitro, cyano, C.sub.1 to C.sub.10 alkyl, C.sub.1 to C.sub.10 halosubstituted alkyl, C.sub.1 to C.sub.6 alkoxy, alkoxycarbonyl having from one to ten carbon atoms in the alkoxy moiety, aminocarbonyl, alkylaminocarbonyl having from one to ten carbon atoms in the alkyl moiety and dialkylaminocarbonyl having from one to ten carbon atoms in each of the alkyl moieties, and the pharmaceutically acceptable salts thereof, inhibit the enzyme lipoxygenase and are useful in treating allergy and inflammatory and cardiovascular conditions for which the action of lipoxygenase has been implicated. These compounds form the active ingredient in pharmaceutical compositions for treating such conditions.

REFERENCES:
patent: 4981865 (1991-01-01), Belliotti et al.
T. A. Hicks et al., J. Med. Chem., 22, No. 12, 1460-1464 (Dec. 1979).

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