Process for the preparation of benzo-(pyrano and thiopyrano)-pyr

Details Process for the preparation of benzo-(pyrano and thiopyrano)-pyr Process for the preparation of benzo-(pyrano and thiopyrano)-pyr

1985-09-26

1988-01-26

Schwartz, Richard A.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

546 80, 546 65, C07D491052, C07D49504

Patent

active

047217871

ABSTRACT:
A process for the preparation of a compound of the formula ##STR1## having a trans 4a,10b-ring junction wherein X represents oxygen or sulfur; ring A is substituted by lower alkoxy; R represents lower alkyl; R.sub.1 -R.sub.5 represent hydrogen; which comprises (a) condensing the corresponding 2H[1]-benzopyran-3-one with the corresponding carboxy protected 3-aminopropanoic acid, (b) reducing and dehydrating the resultant product, and reducing the resulting double bond to a compound of formula I.

REFERENCES:
patent: 3689497 (1972-09-01), Brown
patent: 4198511 (1980-04-01), Connor
patent: 4210758 (1980-07-01), Connor
patent: 4385056 (1983-05-01), Loosen
patent: 4420480 (1983-12-01), Jones
patent: 4439620 (1984-03-01), Klauke et al.
Newkome et al., Contemporary Heterocyclic Chemistry, pp. 286-288, 1982.
Goodman and Gilman, The Pharmacological Basis of Therapeutics, 6 ed., p. 28.
March, Adv. Org. Chem., 2nd ed., p. 1119.
J. Med. Chem. 25, 925 (1982).
Abstract European Patent 99,303.

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