Diphenylpropenamides as SRS-A antagonists

Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Recombinant or stably-transformed bacterium encoding one or...

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562442, A61K 3124, C07C101453

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active

043427812

ABSTRACT:
Certain new diphenylpropenamides having a carboxyalkanamido or a carboxyalkenamido group on one of the phenyl rings and their use for antagonizing the spasmogenic activity of the slow-reacting substance of anaphylaxis (SRS-A) in a human subject. In particular, the compounds of the invention are useful for preventing and treating certain obstructive airways diseases, notably allergic bronchial asthma, allergic rhinitis and certain skin disorders, in human subjects.

REFERENCES:
patent: 3993679 (1976-11-01), Hall et al.
patent: 4036837 (1977-07-01), Sellstedt et al.
patent: 4238506 (1980-12-01), Stach et al.
patent: 4296129 (1981-10-01), Kadin

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