Piperidine derivatives

Details Piperidine derivatives Piperidine derivatives

1980-10-20

1982-08-03

Bond, Robert T.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Bacterium or component thereof or substance produced by said...

546198, 546200, 546201, 544 49, 424267, A61K 31445, C07D41914

Patent

active

043427618

ABSTRACT:
Compounds having the formula ##STR1## wherein Y represents --CHOH-- or ##STR2## Z and Z.sup.1 independently represent ##STR3## --SO.sub.2 --, --COCH.sub.2 --, or --CO(CH.sub.2).sub.2 --; Z may also represent --CH.sub.2 --, --(CH.sub.2).sub.2, --CHMe--, or --CMe.sub.2 --; R.sup.1 and R.sup.2 independently represent hydrogen or substituents selected from halogen, lower-alkoxy, nitro, amino, lower alkylamino, trifluoromethyl, hydroxy, aryl lower alkoxy and lower alkyl; or R.sup.1 and R.sup.2 when adjacent together with the carbon atoms to which they are attached form a six membered carbocyclic ring; R.sup.3 represents hydrogen, halogen, lower alkyl or lower alkoxy, R.sup.4 represents lower alkyl or hydrogen; .alpha. and .beta. each represent hydrogen or a direct bond between the carbon atoms to which they are attached, and acid addition quaternary ammonium salts thereof, are disclosed which possess antihypertensive activity.

REFERENCES:
patent: 4045566 (1977-08-01), Archibold et al.
patent: 4144344 (1979-03-01), Eichenberger et al.
patent: 4224333 (1980-09-01), Clemence et al.
patent: 4281132 (1981-07-01), Ward

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