Anti-spasmodic agents containing quaternary nitrogen

Details Anti-spasmodic agents containing quaternary nitrogen Anti-spasmodic agents containing quaternary nitrogen

1985-07-12

1988-01-26

Schwartz, Richard A.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514320, 514327, 514422, 514424, 514428, 514454, 514513, 546196, 546218, 546239, 548525, 548556, 548572, 549388, 558252, 558256, A61K 31445, C07D40112

Patent

active

047217227

ABSTRACT:
A new class of anti-spasmodic compounds having two branch chains and containing quaternary nitrogen is provided. The compounds have the general formula: ##STR1## wherein R.sub.1 and R.sub.2 are defined hereinbelow and m is an integer from 0 to 3.

REFERENCES:
patent: 2390555 (1945-12-01), Richardson
patent: 4432977 (1984-02-01), Davis
Goodman and Gilman's, The Pharmacological Basis of Therapeutics, 6th ed., MacMillan, New York, 1980, pp. 128-129, 132 and 134.
S. Dupre, et al., Compte Rendue de la Societe de Biologie, 140, pp. 477-479 (1946).
B. Tchoubar, et al., Bulletin de la Societe Chimique, pp. 792-794 (1947).
S. Liberman, Farmakol i. Toksikol., 19(6), pp. 10-17 (1956).
R. O. Clinton, et al., J. Amer. Chem. Soc., 68, pp. 2076-2077 (1946).
Buehler, C., et al., J. Med. Chem., 6, 230-233 (1963).

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