Purfication of blood clotting factors and other blood proteins o

Details Purfication of blood clotting factors and other blood proteins o Purfication of blood clotting factors and other blood proteins o

1985-07-12

1988-01-26

Fisher, Richard V.

Liquid purification or separation

Processes

Liquid/liquid solvent or colloidal extraction or diffusing...

2101982, 2105021, 210656, 502401, 502402, 502407, B01D 1508

Patent

active

047215720

ABSTRACT:
There is disclosed a non-carbohydrate sulfated matrix and the use thereof to isolate and purify blood clotting factors and other blood proteins by a procedure involving the adsorption of at least one of such factors and proteins onto the non-carbohydrate sulfated matrix followed by elution of such factors and proteins onto the non-carbohydrate sulfated matrix followed by elution of such factors and proteins from the matrix.

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D. Menache et al, Blood, 64 (6), 1220-1227 (Dec. 1984), "Coagulation Factor IX Concentrate: Method of Preparation and Assessment of Potential In Vivo Thrombogenicity in Animal Models".
J. P. Miletich et al, Alalytical Biochemistry, 105, 304-310 (1980), "The Synthesis of Sulfated Dextran Beads for Isolation of Human Plasma Coagulation Factors II, IX and X".
"TRISACRYL.RTM. GF 2000", Product Information No. 203108, Reactifs IBF, Societe Chimique Pointet Girard, 92390 Villeneuve-La-Garenne (France).
J. Schutyser et al, "Affinity Chromatography and Related Techniques", TCJ Gribnau et al ed., Elsevier Scientific Publishing Co., 1982, pp. 143-153.

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