Pharmaceutical preparation containing human growth hormone

Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Hormones – e.g. – prolactin – thymosin – growth factors – etc.

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424 4464, 435 694, A61K 3700

Patent

active

060137738

ABSTRACT:
A stable pharmaceutical preparation containing a human growth hormone having a molecular weight of about 20,000, or a derivative thereof, can be formulated by adding a water soluble heterocyclic compound, such as creatinine, a salt of acetyltryptophane and nicotinamide, to prevent the insolubilization of the human growth hormone or the derivative thereof in an aqueous solution.

REFERENCES:
patent: 4980165 (1990-12-01), Isaacs et al.
patent: 5496713 (1996-03-01), Honjo et al.
BIOSIS DN 97128465, Mumenthaler et al., Pharmaceutical Research, 11(1), 12-20. (abstract), 1994.
Abstract 63084500, Patent Abstracts of Japan, vol. 012, No. 312, Aug. 24, 1988.
Rasool et al., Journal of Pharmaceutical Sciences, vol. 80, No. 4, 1991, pp. 387-393.
Gerhard Baumann, "Growth Hormone Heterogeneity: Genes, . . . Proteins"; Endocrine Reviews, vol. 12, No. 4 (1991), 424-449.
George E. Chapman et al., "The 20,000 Molecular . . . Hormone"; The Hournal of Biological Chemistry, vol. 256, No. 5, (1981), 2395-2401.

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