Method of treatment of rheumatoid arthritis

Details Method of treatment of rheumatoid arthritis Method of treatment of rheumatoid arthritis

1982-02-05

1984-12-11

Friedman, Stanley J.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Recombinant or stably-transformed bacterium encoding one or...

424319, A61K 3130, A61K 31195

Patent

active

044877803

ABSTRACT:
Rheumatoid arthritis is treated with substituted cysteine compounds having a lower toxicity-to-effectiveness ratio than penicillamine. Such compounds are specific alpha-substituted cysteines, beta-monosubstituted cysteines, beta-di-substituted cysteines other than penicillamine, N-acetyl penicillamine and the N-acetyl derivatives of the alpha and beta-substituted compounds mentioned above.
Any of the compounds may be used synergistically in combination with suitable copper compounds or with suitable gold compounds in the treatment of arthritis.
The same compounds are effective in the treatment of cystinuria and heavy metal poisoning. The same compounds as well as penicillamine are effective in combination with copper in the treatment of heavy metal poisoning.

REFERENCES:
patent: 3466312 (1969-09-01), Ercoli
patent: 3591686 (1971-07-01), Sheffner et al.
patent: 3792165 (1974-02-01), McGusty et al.
patent: 3842108 (1974-10-01), Sutton et al.
patent: 4112113 (1978-09-01), Hill
patent: 4165380 (1979-08-01), Hill

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