Chemistry of carbon compounds – Miscellaneous organic carbon compounds – C-metal
Patent
1983-06-07
1984-12-11
Torrence, Dolph H.
Chemistry of carbon compounds
Miscellaneous organic carbon compounds
C-metal
544163, 544392, 544395, 546230, 546330, 548566, 549 74, 549491, C07C12178
Patent
active
044877218
ABSTRACT:
The present invention is directed to a process for producing 2-amino-2-arylacetonitriles of general formula I: ##STR1## wherein R and R.sup.1 independently represent hydrogen, hydroxy, hydroxy(C.sub.1 -C.sub.4)alkyl, (C.sub.1 -C.sub.4)alkoxy, (C.sub.1 -C.sub.6)alkyl, 2-furyl, 2-thienyl, 4-pyridinyl, 1-pyrrolydinyl, 1-piperidinyl, 4-morpholinyl, 1-piperazinyl, 4-methyl-1-piperazinyl, 4-phenylpiperazinyl, or phenyl which can optionally be substituted with from 1 to 3 substituents independently selected from (C.sub.1 -C.sub.4)alkyl and (C.sub.1 -C.sub.4)alkoxy, or R and R.sup.1 independently represent a phenyl(C.sub.1 -C.sub.4)alkyl or a phenyl(C.sub.1 -C.sub.4)alkoxy group wherein the phenyl group can be either unsubstituted or substituted as above.
An arylaldehyde derivative of formula II ##STR2## is reacted with chloroform in base and in the presence of ammonia to give the 2-amino-2-arylacetonitrile derivative.
REFERENCES:
patent: 3313683 (1967-04-01), Taylor
patent: 4072698 (1968-02-01), Hylton et al.
patent: 4350641 (1982-09-01), Degner et al.
patent: 4370493 (1983-01-01), Davis, Jr.
Beilstein, 14, 462, (1931).
Gruppo Lepetit S.p.A.
Nesbitt Stephen L.
Stein William J.
Street Gary D.
Torrence Dolph H.
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