Vector and method of use for nucleic acid delivery to non-dividi

Details Vector and method of use for nucleic acid delivery to non-dividi Vector and method of use for nucleic acid delivery to non-dividi

1995-10-06

2000-01-11

Priebe, Scott D.

Chemistry: molecular biology and microbiology

Animal cell, per se ; composition thereof; process of...

514 44, 424 9321, 424 932, 435 691, 4353201, 435455, C12N 1500

Patent

active

060135166

ABSTRACT:
A recombinant retrovirus capable of infecting a non-dividing cell and a method of producing such a virus is provided. The recombinant retrovirus is preferably of lentivirus origin and is useful for the treatment of a variety of disorders including neurological disorders and disorders of other non-dividing cells.

REFERENCES:
patent: 5449614 (1995-09-01), Danos et al.
patent: 5554524 (1996-09-01), Temin et al.
patent: 5580766 (1996-12-01), Mason et al.
patent: 5686279 (1997-11-01), Finer
patent: 5747307 (1998-05-01), Lever
patent: 5750396 (1998-05-01), Yang et al.
patent: 5817491 (1998-10-01), Yee et al.
Crystal, Science, vol. 270, pp. 404-410, 1995.
Dalgleish et al. (Virology, 165, 1988, pp. 209-215).
Landau et al. (J. Virology, vol. 65, No. 1, 1991, pp. 162-169).
Buchschacher et al. (J. Virology, vol. 66, 5:2731-2739, 1992).
Burn et al. (PNAS, vol. 90, Sep. 1993, pp. 8033-8037).
Kim et al. (Virology, 198,336-340, 1994).
Lusso et al., Science, vol. 247, pp. 848-852, 1990.
Ledley, FD. Clinical considerations in the design of protocols for somatic gene therapy. Human Gene Therapy 2:77-83, 1991.
Orkin, SH et al. Report and recommendations of the panel to assess the NIH investment in gene therapy. Issued by National Institutes of Health, Dec. 7, 1995.
Landau, NR et al. Pseudotyping with human T-cell leukemia virus type 1 broadens the human immunodeficiency virus host range. J. Virol. 65:162-169, 1991.
Jon Cohen, New Role for HIV: A Vehicle for Moving Genes into Cells., Science 272:195 (Apr. 12, 1996).
Bukrinsky et al., A Nuclear Localization Signal Within HIV-1 Matrix Protein That Governs Infection of Non-Dividing Cells., Nature., 365:666-669 (Oct. 14, 1993).
Carroll et al., A Human Immunodeficiency Virus Type 1 (HIV-1)- Based Retroviral Vector System Utilizing Stable HIV-1 Packaging Cell Lines., Journal Of Virology., 68(9):6047-6051 (Sep. 1994).
Gallay et al., HIV-1 Infection of Nondividing Cells: C-Terminal Tyrosine Phosphorylation of the Viral Matrix Protein is a Key Regulator., Cell., 80:379-388 (Feb. 10, 1995).
Heinzinger et al., The Vpr Protein of Human Immunodeficiency virus type 1 influences Nuclear Localization of Viral Nucleic Acids in Nondividing Host Cells., Biochemistry., 91:7311-7315 (Jul. 1994).
Lewis et al., Human Immunodeficiency Virus Infection of Cells Arrested in the Cell Cycle., The EMBO Journal., 11(8):3053-3058 (1992).
Page et al., Construction and Use of Human Immunodeficiency Virus Vector for Analysis of Virus Infectivity., Journal of Virology., 64(11):5270-5276 (Nov. 1990).
Poznansky et al., Gene Transfer into Human Lymphocytes by a Detective Human Immunodeficiency Virus Type 1 Vector., Journal Of Virology., 65(1):532-536 (Jan. 1991).
Richardson et al., Helper Virus-Free Transfer of Human Immunodeficiency Virus Type 1 Vectors., Journal of General Virology., 76:691-696 (1995).
Schwedler et al., The Nuclear Localization Signal of the Matrix Protein of Human Immunodeficiency Virus Type 1 Allows the establishment of infection in Macrophages and Quiescent T Lymphocyted., Proc. Natl. Acad. Sci., 91:6992-6996 (Jul. 1994).
Trona et al., HIV-1 Gag Mutants Can Dominantly Interfere with the Replication of the Wild-Type Virus., Cell., 59:113-120 (Oct. 6, 1989).
Naldini et al., "In Vivo Delivery and Stable Transduction of Nondividing Cells by a Lentiviral Vector", Science, vol. 272, Apr. 12, 1996, pp. 263-267.
Lewis et al., "Human Immunodeficiency Virus Infection of Cells Arrested in the Cell Cycle", Oxford University Press, pp. 3053-3058, received on Mar. 20, 1992; revised May 6, 1992.
Heinzinger et al., "The Vpr protein of human immunodeficiency virus type 1 influences nuclear localization of viral nucleic acids in nondividing host cells", Proc. Natl. Acad. Sci., USA, vol. 91, pp. 7311-7315, Jul. 1994, Biochemistry.
Bukrinsky et al., "A nuclear localization signal within HIV-1 matrix protein that governs infection of non-dividing cells", Letters to Nature, vol. 365, Oct. 14, 1993, pp. 666-669.

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