Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Recombinant dna technique included in method of making a...
Patent
1998-08-14
2000-01-11
Caputa, Anthony C.
Chemistry: molecular biology and microbiology
Micro-organism, tissue cell culture or enzyme using process...
Recombinant dna technique included in method of making a...
4353201, 435325, 536 231, C12P 2106, C12N 1500, C12N 500, C07H 2102
Patent
active
060134801
ABSTRACT:
Antagonists of mammalian interleukin-15 ("IL-15") are disclosed and include muteins of IL-15 and modified IL-15 molecules that are each capable of binding to the IL-15R.alpha.-subunit and that are incapable of transducing a signal through either the .beta.- or .gamma.-subunits of the IL-15 receptor complex. Also included are monoclonal antibodies against IL-15 that prevent IL-15 from effecting signal transduction through either the .beta.- or .gamma.-subunits of the IL-15 receptor complex. Methods of treating various disease states are disclosed, including treating allograft rejection and graft-versus-host disease.
REFERENCES:
patent: 4853332 (1989-08-01), Mark et al.
patent: 5206344 (1993-04-01), Katre et al.
patent: 5208020 (1993-05-01), Chari et al.
patent: 5552303 (1996-09-01), Grabstein et al.
patent: 5574138 (1996-11-01), Grabstein et al.
patent: 5696234 (1997-12-01), Zurawski et al.
patent: 5707616 (1998-01-01), Grabstein et al.
patent: 5747024 (1998-05-01), Grabstein et al.
Grabstein, K. et al., "Cloning of a T Cell Growth Factor That Interacts with the .beta. Chain of the Interleukin-2 Receptor", Science 264: 965-968, 1994.
McMahan, C. et al., "A novel IL-1 receptor, cloned from B cells by mammalian expression, is expressed in many cell types", The EMBO Journal 10(10): 2821-2832, 1991.
Giri, J. et al., "Utilization of the .beta. and .gamma. Chains of the IL-2 receptor by the novel cytokine IL-15", The EMBO Journal 13:2822-2830, 1994.
Carson, W. et al., "Interleukin (IL) 15 is a Novel Cytokine that Activates Human Natural Killer Cells via Components of the IL-2 Receptor", Journal Exp. Medicine 180: 1395-1403, Oct. 1994.
Armitage, R. et al., "IL-15 Has Stimulatory Activity of the Induction of B Cell Proliferation and Differentiation", The Journal of Immunology 154: 483-489, 1995.
Tinubu, S. et al., "Humanized Antibody Directed to the IL-2 Receptor .beta.-Chain Prolongs Primate Cardiac Allograft Survival", The Journal of Immunology:4330-4338, 1994.
Sevier, E.D. et al., "Monoclonal Antibodies in Clinical Immunology", Clinical Chemistry 27: 1797-1806, 1981.
Collins, L., et al., "Identification of specific residues of human interleukin 2 that affect binding to the 70-kDa subunit (p70) of the interleukin 2 receptor," Proc. Natl. Acad. Sci. USA 85: 7709-7713, 1988.
Ju, G., et al., "Structure-Function Analysis of Human Interleukin-2," J. Biol. Chem. 262: 5723-5731, 1987.
Zurawski, S., et al., "Definition and spatial location of mouse interleukin-2 residues that interact with its heterotrimeric receptor," EMBO J. 12: 5113-5119, 1993.
Grabstein Kenneth H.
Paxton Raymond J.
Pettit Dean K.
Caputa Anthony C.
Immunex Corporation
Navarro Mark
Smith Julie K.
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