Systematic evolution of ligands by exponential enrichment: tissu

Details Systematic evolution of ligands by exponential enrichment: tissu Systematic evolution of ligands by exponential enrichment: tissu

1997-08-05

2000-01-11

Zitomer, Stephanie W.

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving nucleic acid

435 912, 530350, 530412, 530413, 536 2431, 536 254, 935 77, 935 78, C12Q 168, C12P 1934, C07H 2102, C07K 122

Patent

active

060134437

ABSTRACT:
This invention discloses high-affinity oligonucleotide ligands to complex tissue targets, specifically nucleic acid ligands having the ability to bind to complex tissue targets, and the methods for obtaining such ligands. Tissue targets comprise cells, subcellular components, aggregates or cells, collections of cells, and higher ordered structures. Specifically, nucleic acid ligands to red blood cells ghosts, endothelia of the blood brain and CSF-blood barriers, glioblastomas, and lymphomas are described.

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