Method for treatment of obesity using prolactin modulators and d

Details Method for treatment of obesity using prolactin modulators and d Method for treatment of obesity using prolactin modulators and d

1995-05-10

1998-06-02

Weddington, Kevin E.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514866, 514884, A61K 3144

Patent

active

057600473

ABSTRACT:
The present invention is directed to an improvement in a method of weight and/or body-fat reduction comprising a (preferably moderate) reduction in the caloric intake of a subject in need of such treatment in combination with administration to said subject of a prolactin inhibitor. Additionally, the present invention is directed to an improvement in a method for altering and/or resetting prolactin profiles (and thereby controlling one or more metabolic disorders such as obesity, excessive body fat, hyperlipidemia, hyperlipoproteinemia, hyperglycemia, hypercholesterolemia, hyperinsulinemia, insulin resistance, glucose intolerance, and Type II diabetes) comprising administration to a subject in need of such treatment of a prolactin inhibitor at a predetermined time or times during a 24-hour period in combination with a (preferably moderate) reduction of the caloric intake of said subject.

REFERENCES:
patent: 4219555 (1980-08-01), Rucman
patent: 4239763 (1980-12-01), Milavec
patent: 4659715 (1987-04-01), Meier
patent: 4749709 (1988-06-01), Meier
patent: 4783469 (1988-11-01), Meier
patent: 5006526 (1991-04-01), Meier
Burns et al., Chronopharmacology and Chronotherapeutics, Int'l Symp. on Chronopharm. and Chronother., Florida A&M University, 1978.
Emata et al., J. Exp. Zool., 273:29-34, 1985.
Harel et al., Proc. La. Acad. of Sci., 38:125, 1975.
Joseph et al., Proc. Soc. Exp. Biol. Med., 146:1150-1155, 1974.
Komorowski et al., Aliment. Nutr. Metab. 1(4):293, 1980.
Larsson et al., Lakartidningen (Sweden), 82(50):4425, 293, 1985.
Martin et al., "Hormonal Control of Orientation in the White-Throated Sparrow, Zonotrichia Albicollis." Chronobiology, pp. 641-646, 1974.
Martin et al., Proc. La Acad. of Sci., 38:127, 1975.
Martin et al., Am. Zoologist, 18(3):572, 1978.
Martin, D., "Hormonal Regulation of Migratory Orientation in the White-Throated Sparrow, Zonotrichia Albicollis." Diss. LSU, 1974.
Martin, D., "Factors Influencing the Circadian Rhythm of Locomotor Activity in the Anabatoid Fish, Trichogaster Trichopterus Sumatranus." Thesis. Sam Houston State College, 1969.
Meier, Gen & Comp Endocrinol., Supp. 3:499-508, 1972.
Meier, Gen & Comp Endocrinol., 26:253-258, 1975.
Meier et al., Current Ornithology, 2:303-343, 1984.
Meier et al., Proc. Soc. Exp. Biol. & Med., 137:408-415, 1971.
Meier et al., Physiol. Zool., 41(1):95-103, 1968.
Barnett et al., Postgraduate Med. J. 56:11-14, 1980.
Bartness et al., J. Exp. Zoology 244:437-454, 1987.
Berle, Acta endocr. Suppl. 173, Abstract No. 104, 1973.
Burns, et al., Rev. Chronopharmacology 5:57-60, 1988.
Cassar, J. et al. "Bronocriptine Treatment of Acromegaly," Metabolism 26: 539-546 (1977).
Chemical Abstracts, vol. 109, No. 9, 66888w, Aug. 29, 1988.
Cincotta et al.,Amer. J. of Phsiol. 285-293, Feb 1993.
Cincotta et al., Life Sciences 45:2247-2254, 1989.
Cincotta et al., Ann Nutr Metab 33;305-314, 1989.
Cincotta et al., Horm. Metabol. Res. 21:64-68, 1989.
Cincotta et al., J. Endocrinology 120:385-391, 1989.
Cincotta et al., Experientia 43:416-417, 1987.
Cincotta et al., J. Endocr. 106:177-181, 1985.
Cincotta et al., J. Endocr. 106:173-176, 1985.
Cincotta et al., J. Endoc. 103:141-146, 1984.
Dolocek, R. et al. "Bromocriptine and glucose tolerance in acromegalics," Pharmatherapeutica 3: 100-106 (1982).
Eisemann et al., J. of Animal Sci. 59(1)95-104, 1984.
Eisemann et al., J. of Animal Sci. 59(1)86-94, 1984.
Eskildsen, P.C. et al. "Long-Term Treatment of Acromegaly with Bromocriptine," Acta Endocr. 87: 687-700 (1978).
Gnudi et al., Acta Diabetologica Latin 14:119-128, 1977.
Horseman et al., J. Endocr. 82:367-372, 1979.
Horseman et al., General and Comparative Endocrinology 38:269-274, 1979.
Joseph et al., J. Exp. Zool. 178(1):59-62, 1971.
Landgraf et al., Proc. German Med. Soc. 82nd Convention, Part II, Apr. 25-29, 1976.
Lee et al., J. of Exp. Zool. 166(3):307-316, 1969.
Martin et al., Neuroendocrinology 52: 9-14, 1990.
Martin et al., The Condor 75: 369-374, 1973.
Meier et al., Nature 271:469-471, 1978.
Meier, et al., Experientia 48:248-253, 1992.
Meier, Amer. Zoology, 15:905-916, 1975.
Meier, Amer. Scientist 61(2)184-187, 1973.
Meier, Gen, & Comp. Endocrin. Supp. 2:55-62, 1969.
Meier et al., Gen. & Comp. Endocrin. 8(1):110-114, 1967.
Meier et al., Science 173: 1240-1242, 1971.
Meier et al., Gen. & Comp. Endocrin. 17: 311-318, 1971.
Meier et al., Compar. Endocrin. 141-144, 1978.
Meier et al., Amer. J. of Physiology 232(2):E193-E196, 1977.
Meier et al., Amer. Zool. 16:649-659, 1976.
Southern et al., J. Anim. Sci. 68:931-936, 1990.
Spieler et al., Gen. & Comparative Endocrinology 29:156-160, 1976.
Spieler et al., Life Sciences 22:255-258, 1977.
Steinbeck, K. and J.R. Turtle, "Treatment of Acromegalywith Bromocryptine," Aust. N.Z. J. Med.9: 217-224 (1979).
Thomas et al., Semaine des Hopitaux de Paris 53(34-35): 1857-1862, 1977.
Wheeland, et al., Comp. Biochem. Physiol. vol. 53B; 379-385, 1976.
Wilson et al., Chronobiology Int'l 6(2):113-121, 1989.3:189-195, 1989.
Wass, J.A.H. et al. "An Assessment of Glucose Intolerance In Acromegaly and Its Response to Medical Treatment," Clin. Endocr. 12:53-59 (1980).

Affiliated with

Also associated with

Rating

Method for treatment of obesity using prolactin modulators and d does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Method for treatment of obesity using prolactin modulators and d, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Method for treatment of obesity using prolactin modulators and d will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1460120