Griseolic acid derivatives, their preparation and their use

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

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544277, A61K 3152, C07D47304, C07D47316, C07D47318

Patent

active

057600422

ABSTRACT:
New griseolic acid derivatives have various groups attached to the sugar part in place of the adenine group of griseolic acid itself. These groups are all purine derivatives or ring-opened purine analogs. The compounds are useful as inhibitors of phosphodiesterases.

REFERENCES:
patent: 4035370 (1977-07-01), Lorincz et al.
patent: 4167565 (1979-09-01), Stein et al.
patent: 4460765 (1984-07-01), Naito et al.
patent: 4634706 (1987-01-01), Kaneko et al.
patent: 4783532 (1988-11-01), Kaneko et al.
patent: 4803271 (1989-02-01), Verheyden et al.
patent: 4822879 (1989-04-01), Nakagawa et al.
patent: 5091431 (1992-02-01), Tulshian et al.
N. D. Goldberg et al, "Biologic Regulation Through Opposing Influences of Cyclic GMP and Cyclic AMP: The Yin Yang Hypothesis", pp. 307-330, 1975, Advances in Cyclic Nucleotide Research, vol. 5.
Joseph Segal, "Opposite Regulatory Effects of cAMP and cGMP on Sugar Uptake in Rat Thymocytes", 1987, pp. E588-E594, AM, J. Physiol., 252.
Daiichi Seiyaku, "Bucladesine Sodium", vol. 10, No. 2, 1985 Drugs of the Future.
M. Hagiwara et al, "Effects of Vinpocetine on Cyclic Nucleotide Metabolism in Vascular Smooth Muscle", vol. 33, No. 3, pp. 453-457, 1984, pp. 453-457, Biochemical Pharmacology.
Tohru Ueda, Kazunobu Miuyra and Tsuguo Kasai, "Synthesis of 6-Thioguanine and 2,6-Diaminopurine Nucleosides and Nucleotides from Adenine Counterparts via a Facile Rearrangement in the Base Portion (Nucleosides and Nucleotides. XIX)".
Chem. Pharm. Bull., 26, 2122-2127 (1978).
Chemical Abstracts, vol. 106, No. 7, 1987, pp. 683-684, Abstract No. 50602a of JP 61-100593 which was published May 1986.

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