Fused benzeneoxyacetic acid derivatives which have PGI.sub.2 rec

Details Fused benzeneoxyacetic acid derivatives which have PGI.sub.2 rec Fused benzeneoxyacetic acid derivatives which have PGI.sub.2 rec

1996-09-27

1998-12-15

Shah, Mukund J.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

5483001, 5483561, 5483351, 546 1, C07D23104, C07D23300

Patent

active

058499199

ABSTRACT:
A fused benzeneoxyacetic acid derivative of the formula (I): ##STR1## wherein D is a 3-5-membered ring;
B is a C.sub.1-4 group;
R.sup.1 is OH alkoxy, (alkyl) amino, residue of an amino acid;
A is phenyl, alkyl substituted by phenyl, residue of an imidazole, imidazole-2-yloxy(thio), 2-oxoimidazole, pyrazole, oxadiazole, oxazole, trizole, isoxazole or isothiazole, in the group of benzene may be substituted by one to three of alkyl, alkoxy, halogen, nitro or trihalomethyl;
and salts thereof possess an agonistic effect on the PGI.sub.2 receptor, so is useful for prevention and/or treatment of thrombosis, arteriosclerosis, ischemic heart diseases, gastric ulcer and hypertension.

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