Biologically active phosphotriester-type nucleosides and methods

Details Biologically active phosphotriester-type nucleosides and methods Biologically active phosphotriester-type nucleosides and methods

1996-09-13

1998-12-15

Wilson, James O.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

536 2671, 536 2672, 536 2674, 536 268, 536124, C07H 100, C07H 1900

Patent

active

058499059

ABSTRACT:
Compounds of formula RS--P(.dbd.O) (QR)--Nu where: R is a radical --(CH.sub.2)n-W--X; X is a radical --C(.dbd.Z) (Y) or --S--U; Z is O or S; W is O or S; Q is O or S; Y and U are an alkyl, aryl or saccharide radical which is optionally substituted with, for example, an OH, SH or NH group; n is equal to 1 to 4, preferably 1 or 2; and Nu is a radical consisting of a residue of a biologically active compound or the dephosphorylated residue of a compound which is biologically active when it bears a phosphate or phosphonate group.

REFERENCES:
patent: 5430136 (1995-07-01), Urdea et al.
patent: 5430138 (1995-07-01), Urdea et al.
Hao et al., "Potent DNA Chain Termination Activity and Selective Inhibition of Human Immunodeficiency Virus Reverse Transcriptase by 2', 3'-Dideoxyuridine-5'-triphosphate", Molecular Pharmacology, 1990, 37, 157-163.
Hao et al., "2',3'-Dideoxyuridine Triphosphate: A Potent Inhibitor of HIV Reverse Transcriptase", Proceedings of AACR, 1988, 29, 348.
Matthes et al., "Inhibition of HIV-Associated Reverse Transcriptase by Sugar-Modified Derivatives of Thymidine 5'-Triphosphate in Comparison to Cellular DNA Polymerases .alpha. and .beta.", Biochem. And Biophys. Res. Commun., 1987, 148 (1), 78-85.
Rosenberg et al., "Synthesis ofPotential Prodrugs and Metabolites of 9-(S)--(3-Hydroxy-2-Phosphonylmethoxypropyl) Adenine", Coll. Czechoslovak Chem. Comm., 1987, 52, 2792-2800.
Pompon et al., "On-line Internal Surface Reversed-Phase Cleaning: The Direct HPLC Analysis of Crude Biological Samples", Biochem. Pharm., 1992, 43, 1769-1775.
Rosenberg et al., "Synthesis of Potential Prodrugs and metabolites of 9-(S)--(3-Hydroxy-2-Phosphonylmethoxypropyl) Adenine", Collection Czechoslovak Chem. Commun., 1987, 52, 2792-2800.
Hanes et al., "Separation of the Phosphoric Esters on the Filter Paper Chromatogram", Nature, 1949, 164, 1107-1112.
Wiesler et al., "Synthesis and Purification of Phosphorodithioate DNA", Methods in Molecular Biology: Protocols for Nucleotides and Analogs, S. Agrawal (ed.), Humana Press Inc., Totowa, NJ, 1993, 20, 191-206.
Miles et al., "Dithiols. Part XII. The Alkaline Hydrolysis of Acetylated Hydroxy-thiols: A New Reaction for the Formation of Cyclic Sulphides", J. Chem. Soc., 1952, 817-826.
Lefebvre et al., "Mononucleoside Phosphotriester Derivatives with S-Acyl-2-thioethyl Bioreversible Phosphate-Protecting Groups: Intracellular Delivery of 3'-Azido-2',3'-dideoxythymidine 5'-Monophosphate", J. Med. Chem., 1995, 38, 3941-3950.

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