Human tumor suppressor

Organic compounds -- part of the class 532-570 series – Organic compounds – Carbohydrates or derivatives

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536 231, 536 2431, 4353201, 435 691, 4352523, C07H 2104, C12N 1563, C12N 121

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active

058498990

ABSTRACT:
The present invention provides a human tumor suppressor (TUPRO-2) and polynucleotides which identify and encode TUPRO-2. The invention also provides expression vectors and host cells, agonists, antibodies, or antagonists. The invention provides methods for treating diseases associated with expression of TUPRO-2.

REFERENCES:
Burgess et al. J. Cell Biol. 11:2129-2138, 1990.
Lazar et al. Mol. Cell. Biol. 8:1247-1252, 1988.
Tao et al. J. Immunol. 143(8):2595-2601, 1989.
Gillier et al. Human Antibodies & Hybridoma, 1(1):47-54, 1990.
Hillier, L. et al. GenBank, Accession Nos. M49458, R50367, 1995.
Knudson, A., "Antioncogenes and human cancer," Proc. Natl. Acad. Sci. USA, 90:10914-10921 (1993).
Antelman, D., et al., "Inhibition of tumor cell proliferation in vitro and in vivo by exogenous p110.sup.RB, the retinoblastoma tumor suppressor protein," Oncogene, 10:697-704 (1995).
Hamada, K., et al., "Adenovirus-mediated Transfer of a Wild-Type p53 Gene and Induction of Apoptosis in Cervical Cancer," Cancer Research, 56:3047-3054 (1996).
Todd, R., et al., "Deleted in oral cancer-1 (doc-1), a novel oral tumor suppressor gene," The FASEB Journal, 9:1362-1370 (1995) (GI 606837).
Gordon, H. et al., "Tumor Necrosis Factor Induces Genes Involved in Inflammation, Cellular and Tissue Repair, and Metabolism in Murine Fibroblasts," The Journal of Immunology, 148(12):4021-4027 (1992) (GI 202234).
Chang, F., et al., "Implications of the p53 Tumor-Suppressor Gene in Clinical Oncology," Journal of Clinical Oncology, 13(4):1009-1022 (1995).
Jacobson, D., et al., "Molecular genetic tumor markers in the early diagnosis and screening of non-small-cell lung cancer," Annals of Oncology, 6(3):S3-S8 (1995).
Vokes, E., et al., "Head and Neck Cancer," The New England Journal of Medicine, 328(3):184-194.
Silverman, S., et al., "Epidemiologic and demographic update in oral cancer: California and national data-1973 to 1985," JADA, 120:495-499 (1990).
Wong, D.T. (Direct Submission), GenBank Sequence Database (Accession U10249), National Center for Biotechnology Information, National Library of Medicine, Bethesda, Maryland, 20894, (GI 606837). 20 Mar. 1996.
Wong, D.T. (Direct Submission), GenBank Sequence Database (Accession U10249), National Center for Biotechnology Information, National Library of Medicine, Bethesda, Maryland, 20894, (GI 606836). 21 Mar. 1996.
Database EMBL, entry HS1146816, Accession No. AA227129, Feb. 27, 1997.
Database EMBL, entry HS458284, Accession No. N49458, Feb. 18, 1996.
Database EMBL, entry HS683280, Accession No. N48683, Feb. 18, 1996.

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