Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Recombinant dna technique included in method of making a...
Patent
1996-11-15
1998-06-02
Feisee, Lila
Chemistry: molecular biology and microbiology
Micro-organism, tissue cell culture or enzyme using process...
Recombinant dna technique included in method of making a...
5362311, 536 2431, 536 245, 536 235, 4353201, 43525233, 435 711, C12N 1511, C12N 120, C12N 1563, C07H 2104
Patent
active
057598126
ABSTRACT:
The present invention provides a human selenium-binding protein (HSEBP) and polynucleotides which identify and encode HSEBP. The invention also provides genetically engineered expression vectors and host cells comprising the nucleic acid sequences encoding HSEBP and a method for producing HSEBP. The invention also provides for agonists and antibodies specifically binding HSEBP, and their use in the prevention and treatment of diseases associated with expression of HSEBP. Additionally, the invention provides for the use of antisense molecules to polynucleotides encoding HSEBP for the treatment of diseases associated with the expression of HSEBP. The invention also provides diagnostic assays which utilize the polynucleotide, or fragments or the complement thereof, and antibodies specifically binding HSEBP.
REFERENCES:
Knekt et al., "Serum Selenium and Subsequent Risk of Cancer Among Finnish Men and Women," Journal of National Cancer Institute, 82(10):864-868 (1990).
Handel et al., "Inhibition of AP-1 binding and transcription by gold and selenium involving conserved cysteine residues in Jun. and Fos," Proc. Natl. Acad. Sci. USA, 97:4497-4501 (1995).
Bansal, "DNA sequencing of a mouse liver protein that binds selenium: implications for selenium's mechanism of action in cancer prevention," Carcinogenesis, 11(11):2071-2073 (1990) (GI 227630).
Bartolone et al., "Purification, Antibody Production, and Partial Amino Acid Sequence of the 58-kDa Acetaminophen-Binding Liver Proteins," Toxicology and Applied Pharmacology, 113:19-29 (1992).
Lanfear et al., "Different patterns of regulation of the genes encoding the closely related 56 kDA selenium-and acetaminophen-binding proteins in normal tissues and during carcinogenesis," Carcinogenesis, 14(3):335-340 (1993) (GI 298710).
Ishii et al., "Significant induction of a 54-kDa protein in rat liver with homologous alignment to mouse selenium binding protein by a coplanar polychlorinated biphenyl, 3, 4, 5, 3', 4'-pentachlorobiphenyl and 3-methylcholanthrene," Toxicology Letters, 87:1-9 (1996).
Spyrou et al., "AP-1 DNA-binding activity is inhibited by selenite and selenodiglutathione," FEBS Letters, 368:59-63 (1995).
Morrison et al., "Intracellular 58-kd selenoprotein levels correlate with inhibition of DNA synthesis in mammary epithelial cells," Carcinogenesis, 9(10):1801-1810 (1988).
Chang et al., (GI 1374792), GenBank Sequence Database (Accession 1374792), National Center for Biotechnology Information, National Library of Medicine, Bethesda, Maryland 2084.
Bandman Olga
Hawkins Phillip R.
Bansal Geetha P.
Billings Lucy J.
Feisee Lila
Incyte Pharmaceuticals Inc.
LandOfFree
Human selenium-binding protein does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Human selenium-binding protein, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Human selenium-binding protein will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1458520