Storage-stable prostaglandin compositions

Details Storage-stable prostaglandin compositions Storage-stable prostaglandin compositions

1996-10-29

1998-12-15

Gerstl, Robert

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Ester doai

514570, 514571, 514573, A61K 31557

Patent

active

058497927

ABSTRACT:
The use of polyethoxylated castor oils in prostaglandin compositions greatly enhances the prostaglandin's chemical stability.

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patent: 5110493 (1992-05-01), Cherng-Chyi et al.
patent: 5185372 (1993-02-01), Ushio et al.
Attwood and Florence, "Reactivity in surfactant systems," Surfactant Systems, Their Chemistry, Pharmacy and Biology, 11:698-777, Chapman and Hall, Publ.
Foster et al., "Intraocular Penetration of Miconazole in Rabbits," Arch. ophthalmol. 97/9, pp. 1703-1706 (1979) (abstract only).
Sayed and Repta, "Solubilization and stabilization of an investigational antineoplastic drug (NSC No. 278214) in an intravenous formulation using an emulsion vehicle," Internat'l J. of Pharmaceutics, vol. 13 (1983), pp. 302-312.

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