Tetrahydropyridine derivatives as dopamine receptor subtype liga

Details Tetrahydropyridine derivatives as dopamine receptor subtype liga Tetrahydropyridine derivatives as dopamine receptor subtype liga

1997-03-07

1998-12-15

Daus, Donald G.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514337, 514339, 5462701, 5462717, 5462734, 5462774, 5462804, 5462841, A61K 31425

Patent

active

058497650

ABSTRACT:
A class of 1,2,3,6-tetrahydropyridine derivatives, substituted in the 4-position by a fused bicyclic heteroaromatic moiety and in the 1-position by an optionally substituted benzyl moiety, are ligands for dopamine receptor subtypes within the body, in particular the D.sub.4 subtype, and are therefore useful in the treatment and/or prevention of disorders of the dopamine system, in particular schizophrenia or depression.

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