Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...
Patent
1995-04-14
1998-12-15
MacMillan, Keith D.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Heterocyclic carbon compounds containing a hetero ring...
514626, 514567, 514315, 514255, 5142378, A61K 31535, A61K 3116
Patent
active
058497374
ABSTRACT:
Compositions and methods for alleviating pain (in particular, neuropathic pain) in a mammalian patient, wherein an effective amount of a physiologically-acceptable salt of a compound of the general formula ##STR1## wherein each of R.sup.1, R.sup.2 and R.sup.3 is independently selected from the group consisting of hydrogen, hydroxyl, acyl, alkoxyl, alkyl, aryl, alkylaryl, arylalkyl, hydroxyalkyl, hydroxyaryl, alkoxyalkyl, alkoxyaryl and NR.sup.8 R.sup.9, in which each of R.sup.8 and R.sup.9 is independently selected from the group consisting of hydrogen, alkyl, aryl, acyl, alkylaryl, arylalkyl, hydroxyalkyl, hydroxyaryl, alkoxyalkyl and alkoxyaryl, with the proviso that at least one of R.sup.1, R.sup.2 and R.sup.3 is hydroxyl;
REFERENCES:
patent: 5389630 (1995-02-01), Sah et al.
TOXLIT abstract AN 90:30068, Oda et al, "Metabolism of lidocaine by purified rat liver microsomal cytochrome P-450 isozymes", Biochem Paharmacol, vol. 38, No. 24., pp. 4439-4444, Jan. 1989.
Anesthesiology (1979) 51: 2; 123-126, Dohi S., et al., An Analgesic Action of Intravenously Administered Lidocaine on Dorsal-Horn neurons Responding to Noxious Thermal Stimulation.
Anesthesiology (1992) 76;513-517, Chabal C., et al., The Use of Oral Mexiletine for the Treatment of Pain after peripheral Nerve Injury.
Anesthesiology (1994) 80:2; 383-391, Abram S.E., et al., Systemic Lidocaine Blocks Nerve Injury-Induced Hyperalgesia and Nociceptor-Driven Spinal Sensitization in the Rat.
Brain Res. (19192) 603:2201-206, Biella G., et al., Central Effects of Systemic Lidocaine Mediated by Glycine Spinal Receptors: An Iontophoretic Study in the Rat Spinal Cord.
Br. Med. J. (1986) 292:173, Kastrup J., et al., Treatment of Chronic Painful Diabetic Neuropathy with Intravenous Lidocaine Infusion.
Can. Med. Assoc. J. (1943)49:478-481, Gordon R.A., Intravenous Novocaine for Analgesia in Burns.
Clin. J. Pain (1989)5:3239-244, Kastrup J., et al., Lidocaine Treatment of Painful Diabetic Neuropathy and Endogenous Opioid Peptides in Plasma.
Clin. Pharm. Ther. (1978) 24:654-662, Narang P.K., et al., Lidocaine and Its Active Metabolites.
JAMA (1961) 176:1041-1043, Shanbrom E., Treatment of Herpetic Pain and Postherpetic Neuralgia with Intravenous Procaine.
Pharmacol. Exp. Ther. (1972) 180:454-463, Keenaghan J.B., et al., The Tissue Distribution, Metabolism and Excretion of Lidocain in Rats, Guinea Pigs, Dogs and Man.
Journal of the American Academy of Dermatology (1986) 15:2:383-385, Juhlin L., Long-standing Pain Relief of Adiposis Dolorosa(Dercum's Disease) after Intravenous Infusion of Lidocaine.
Lancet (1988) 1:8575-6:9-11, Dejg.ang.rd A., et al., Mexilitine for Treatment of Chronic Painful Diabetic Neuropathy.
Neurology (1991) 41:7; 1024-1028, Rowbotham M.C., et al., Both Intravenous Lidocaine and Morphine Reduce the Pain of Postherpetic Neuralgia.
Pain(1985)23:361-374, Woolf C.J., et al., The Systemic Administration of Local Anesthetics Produces a Selective Depressions of C-afferent Fibre Evoked Activity in the Spinal Cord.
Pain(1987)28:69-75, Kastrup J., et al., Intravenous Lidocaine Infusion--A New Treatment of Chronic Painful Diabetic Neuropathy?.
Pain(1987)28:45-50, Lindstrom P., et al., The Analgesic Effect of Tocainide in Trigeminal Neuralgia.
Pain(1987)28:1;77-80, Peterson P., et al., Dercum's Disease (Adiposis Dolorosa). Treatment of the Severe Pain with Intravenous Lidocaine.
Pain(1989)38:333-338, Chabal C., et al., The effect of Intravenous Lidocaine, Tocainide, and Mexiletine on Spontaneously Active Fibers Originating in Rat Sciatic Neuromas.
Pain(1990)40:129-34, Bach F.W., et al., The Effect of Intravenous Lidocaine on Nociceptive Processing in Diabetic Neuropathy.
Pain(1991)45:2; 145-148 Brose, W.G., et al., Subcutaneous Lidocaine for Treatment of Neuropathic Cancer Pain.
Pain(1992)48:2;261-268, Devor M., et al., Systemic Lidocaine Silences Ectopic Neuroma and DRG Discharge without Blocking Nerve Conduction.
Pain(1992)50:3; 355-363, Kim S.H., et al., An Experimental Model for Peripheral Neuropathy Produced by Segmental Spinal Nerve Ligation in the Rat.
Pain(1992)48:377-382, Marchettini P., et al., Lidocaine Test in Neuralgia.
Reg. Anesth.(1985)10:1-6, Edwards W.T., et al., Intravenous Lidocaine in the Management of Various Chronic Pain States; a Review of 211 Cases.
Somatosensory and Motor Research (1992)9;3; 227-233, Sotgiu M.L. et al., Effect of Systemic Lidocain on Dorsal horn neuron Hyperactivity Following Chronic Peripheral Nerve Injury in Rats.
The Medical Journal of Australia (1960); 27-28, Collins E.B., The Use of Intravenous Procaine Infusion in the Treatment of Postherpetic Neuralgia.
Chemical Abstracts AN 1989:212291, Hisamichi et al., 1987.
Chemical Abstracts AN 1980:22210, Minasyan et al, 1979.
Bach Flemming Winther
Chaplan Sandra Reading
Yaksh Tony Lee
MacMillan Keith D.
The Regents of the University of California
LandOfFree
Compositions and methods for treating pain does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Compositions and methods for treating pain, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Compositions and methods for treating pain will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1458138