Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai
Patent
1995-06-06
1998-12-15
Feisee, Lila
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Peptide containing doai
530300, 530317, A61K 3800
Patent
active
058497080
ABSTRACT:
A method for promoting eating, the gain of weight or maintenance of weight in a subject. The method includes administering to the subject an effective amount of melanocyte concentrating hormone (MCH) or agonist thereof.
REFERENCES:
patent: 5049655 (1991-09-01), Vaughan et al.
patent: 5210076 (1993-05-01), Berliner et al.
patent: 5449766 (1995-09-01), Vaughan et al.
patent: 5530095 (1996-06-01), Vaughn et al.
Lewin et al Science 237:1570, 1987.
Reeck Cell 50:667, Aug. 1987.
Presse et al Neuroscience vol. 71 No. 3 735-745, 1996.
Rossi et al Endinocrinology vol. 138 No. 1 351, 1997.
Qu et al Nature vol. 380 243, Mar. 1996.
Nahon, "The malanin-concentrating hormone: from the peptide to the gene" Crit. Rev. in Neurobiology 8(4):221-262 (1994).
Baile et al., "Role of Cholecystokinin and Opioid Peptides in Control of Food Intake," Physiol. Reviews, vol. 66, No. 1, 172-234 (1986).
Baker, B., "Melanin-concentrating Hormone Updated, Functional Considerations," TEM, vol. 5, No. 3, 120-126 (1994).
Bray, GA, "1989 McCollum Award Lecture. Genetic and Hypothalamic Mechanisms for Obesity-Finding the Needle in the Haystack," Am J. Clin. Nutr., vol. 50, 891-902 (1989).
Bresson et al., "Donnees Ontogenetiques sur la Population d'interneurones Peptidergiques a Immunoreactivite de Type GRF.sub.37 de L'hypothalamus Postero-Lateral Humain. Etudes Immunocytochimiques a L'aide d'un IS Anti-GRF.sub.37 et d'un IS Anti-MCH (melanin-concentrating hormone)," CR Soc. Biol., vol. 181, 376-382 (1987); A Abstract, Only.
Breton et al., "Structure and Regulation of the Mouse Melanin-Concentrating Hormone mRNA and Gene," Molecular and Cellular Neurosciences, vol. 4, 271-284 (1993).
Castrucci et al., "A Teleost Skin Bioassay for Melanotropic Peptides," Gen. Comp. Endocrinol., vol. 66, 374-380 (1987).
Castrucci et al., ".alpha.-Melanotropin: The Minimal Active Sequence in the Lizard Skin Bioassay," Gen. Comp. Endocrinol., vol. 73, 157-163 (1989).
Drozdz, R. and Eberle, A., "Binding Sites for Melanin-Concentrating Hormone (MCH) in Brain Synaptosomes and Membranes From Peripheral Tissues Identified with Highly Tritiated MCH," J. of Receptor and Signal Transduction Research, vol. 15(1-4), 487-502 (1995).
Drozdz, R. and Eberle, A., "Synthesis and Iodination of Human (Phenylalanine .sup.13 Tyrosine .sup.19) Melanin-concentrating Hormone for Radioreceptor Assay," Journal of Peptide Science, 23rd European Peptide Symphosium, Braga, Portugal, vol. 1, 55-65 (1994).
Griffond et al., "The Synthesis of Melanin-concentrating Hormone is Stimulated by Ventromedial Hypothalamic Lesions in the Rat Lateral Hypothalamus: A Time-course Study," Neuropeptides, vol. 28, 267-275 (1995).
Hadley et al., "Differential Structural Requirements for the MSH and MCH Activities of Melanin Concentrating Hormone," Life Sci., vol. 40, 1139-1145 (1987).
Hogben, L. and Slome, D., "The Pigmentary Effector System. VI. The Dual Character of Endocrine Co-ordination in Amphibian Colour Change," Proc. Roy. Soc., B, vol. 108, 10-53 (1931).
Hruby et al., ".alpha.-Melanotropin: The Minimal Active Sequence in the Frog Skin Bioassay," J. Med. Chem., vol. 30, 2126-2130 (1987).
Kawauchi et al., "Characterization of Melanin-concentrating Hormone in Chum Salmon Pituitaries," Nature, vol. 305, 321-323 (1983).
Kawauchi, H. and Kawazoe, I., "Structure-activity Studies on Melanin-concentrating Hormone," Advances in Pigment Cell Res., 517-525 (1988).
Lebl et al., "Melanin Concentrating Hormone Analogues: Contration of the Cyclic Structure 1. Agonist Activity," J. Med. Chem., vol. 31, 949-954 (1988).
Lebl et al., "Melanin Concentrating Hormone Analogues: Contraction of the Cyclic Structure. II. Antagonist Activity," Life Sci., vol. 44, 451-457 (1989).
Liang, P. and Pardee, A., "Differential Display of Eukaryotic Messenger RNA by Means of the Polymerase Chain Reaction," Science, vol. 257, 967-971 (1992).
Matsunaga et al., "Melanin Concentrating Hormone (MCH): Synthesis and Bioactivity Studies of MCH Fragment Analogues," Peptides, vol. 10, 349-354 (1989).
Matsunaga et al., "Synthesis and Bioactivity Studies of Two Isosteric Acyclic Analogues of Melanin Concentrating Hormone," Life Sci., vol. 51, 679-685 (1992).
Morley, J., "Neuropeptide Regulation of Appetite and Weight," Endocrin. Rev., vol. 8, No. 3, 256-87 (1987).
Nahon et al., "Structure and Regulation of the Melanin-Concentrating Hormone Gene.sup.a," Ann. NY Acad. Sci., vol. 680, 111-129 (1993).
Naito et al., "Melanin-concentrating Hormone-like Immunoreactive Material in the Rat Hypothalamus; Characterization and Subcellular Localization," Cell Tissue Res., vol. 253, 291-295 (1988).
Parkes et al., "Secretion of Melanin-concentrating Hormone and Neuropeptide-El from Cultured Rat Hypothalmic Cells," Endocrinology, vol. 131, No. 4, 1826-1831 (1992).
Pesonen et al., "Hypothalamic Neuropeptide Expression After Food Restriction in Zucker Rats: Evidence of Persistent Neuropeptide Y Gene Activation," Molecular Brain Research, vol. 16, 255-260 (1992).
Sanacora et al., "Increased Hypothalamic Content of Preproneuropeptide Y Messenger Ribonucleic Acid in Genetically Obese Zucker Rats and Its Regulation by Food Deprivation," Endocrinology, vol. 127, No. 2, 730-736 (1990).
Skofitsch et al., "Immunohistochemical Localization or a Melanin Concentrating Hormone-Like Peptide in the Rat Brain," Brain Research Bulletin, vol. 15, 635-649 (1985).
Stanley et al., "Repeated Hypothalamic Stimulation with Neuropeptide Y Increases Daily Carbohydrate and Fat Intake and Body Weight Gain in Female Rats," Physiol. and Behav., vol. 46, 173-177 (1989).
Tsujii et al., "GABA-related Feeding Control in Genetically Obese Rats," Brain Research, vol. 540, 48-54 (1991).
Wilding et al., "Increased Neuropeptide Y Content in Individual Hypothalmic Nuclei, but not Neuropeptide Y mRNA, in Diet-induced Obesity in Rats," J. Endocrinol., vol. 132, 299-304 (1992).
Wilding et al., "Increased Neuropeptide-Y Messenger Ribonucleic Acid (mRNA) and Decreased Neurotensin mRNA in the Hypothalamus of the Obese (ob/ob) Mouse," Endocrinology, vol. 132, No. 5, 1939-1944 (1993).
Williams et al., "Hypothalamic Regulatory Peptides in Obese and Lean Zucker Rats," Clinical Science, vol. 80, 419-426 (1991).
Zamir et al., "Melanin-concentrating Hormone: Unique Peptide Neuronal System in the Rat Brain and Pituitary Gland," Proc. Natl. Acad. Sci. USA, vol. 83, 1528-1531 (1986).
Zhang et al., "Positional Cloning of the Mouse Obese Gene and its Human Homologue," Nature, vol. 372, 425-432 (1994).
Feisee Lila
Joslin Diabetes Center, Inc.
Reeves Julie E.
LandOfFree
Promotion of eating behavior does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Promotion of eating behavior, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Promotion of eating behavior will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1457944