Organic compounds -- part of the class 532-570 series – Organic compounds – Carbohydrates or derivatives
Patent
1995-06-05
1999-11-09
Caputa, Anthony C.
Organic compounds -- part of the class 532-570 series
Organic compounds
Carbohydrates or derivatives
536 2431, 4353201, C12N 1512
Patent
active
059817232
ABSTRACT:
We have discovered a nuclear protein in normal human cells, "retinoblastoma-associated protein 1" ("RBAP-1") that binds directly to the retinoblastoma protein pocket of the underphosphorylated form of the retinoblastoma protein ("RB") and does not bind to phosphorylated RB or to RB with inactivating mutations. The translated RBAP-1 sequence does not resemble other proteins whose sequences are known, and RBAP-1 does not contain a sequence homologous to the transforming element common to viral proteins that bind to the RB pocket. RBAP-1 and the E2F transcription activity have similar DNA-binding specificities and can bind to at least some of the same proteins, such as RB and E4.
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DeCaprio James A.
Flemington Erik
Kaelin, Jr. William G.
Livingston David M.
Sellers William
Caputa Anthony C.
Dana-Farber Cancer Institute
Eisenstein Ronald I.
Hayes Robert C.
Resnick David S.
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