Process for selectively controlling unwanted expression or funct

Organic compounds -- part of the class 532-570 series – Organic compounds – Carbohydrates or derivatives

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260112R, 435240, 435241, 536 28, 536 29, C07H 1512, C07H 1700

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045117136

ABSTRACT:
A process for selectively controlling or interfering with the effect or function of foreign nucleic acid in the presence of otherwise normal living cells which comprises determining the base sequence for the nucleic acid and binding the nucleic acid with an appropriately prepared nonionic oligonucleoside alkyl or arylphosphonate analogue which is complementary to the indicated sequence of the foreign nucleic acid.

REFERENCES:
patent: 3560478 (1971-02-01), Myers
Chemical Abstracts 91: 205795p, (1979).
Jayaraman et al., Pra. Natl. Acad. Sci. U.S.A., vol. 78, No. 3, pp. 1537-1541, Mar. 1981.
Miller et al., Biochemistry, 1981, 20, 1874-1880.
Miller et al., Biochemistry, (1977), 16, 1988-1996.
Miller et al., Fed. Pro. Abst., 36,695, (1977), Abst. No. 2231.

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