Substituted heterocyclylalkyl esters of 1,4-dihydropyridine-3,5-

Details Substituted heterocyclylalkyl esters of 1,4-dihydropyridine-3,5- Substituted heterocyclylalkyl esters of 1,4-dihydropyridine-3,5-

1985-01-22

1990-01-09

Hollrah, Glennon H.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

514218, 514252, 514254, 514333, 514338, 514341, 540575, 544360, 544364, 544365, 546256, 546271, 546278, A61K 31495, C07D40112

Patent

active

048928755

ABSTRACT:
Dihydropyridine derivatives and acid addition salts thereof which are of use as prophylactic or/and therapeutic drugs for cardiovascular diseases, said dihydropyridine derivatives having the formula ##STR1## wherein R.sup.1, R.sup.2 and R.sup.3 are the same or different and each is alkyl, cycloalkyl, cycloalkylalkyl or alkoxyalkyl; R.sup.4 and R.sup.5 are the same or different and each is hydrogen, halogen, nitro, trifluoromethyl, alkyl, cycloalkyl, alkoxy, cyano, alkoxycarbonyl or alkylthio; R.sup.6 is hydrogen, alkyl, cycloalkyl, aralkyl, aryl or a pyridyl; X is oxygen, sulfur, vinylene, azomethine or a group of the formula ##STR2## A is alkylene; Ar is aryl or a pyridyl; m is an integer of 1 to 3; n is an integer of 0 to 2.

REFERENCES:
patent: 3472853 (1969-10-01), Archer
patent: 3905970 (1975-09-01), Bossert et al.
patent: 3959292 (1976-05-01), Meyer et al.
patent: 4380547 (1983-04-01), Materne
Yoshitomi Pharm, Derwent Abstract, 92122 (11-4-81).

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