Drug – bio-affecting and body treating compositions – Enzyme or coenzyme containing – Oxidoreductases
Patent
1995-03-29
1998-06-02
Naff, David M.
Drug, bio-affecting and body treating compositions
Enzyme or coenzyme containing
Oxidoreductases
134 10, 134 26, 1341041, 134201, 134901, 25218628, 422 30, 422292, 424484, 424616, 435174, 435262, 435264, 435288, 50418631, A61K 3844, A61K 914, C12N 1100
Patent
active
057595402
DESCRIPTION:
BRIEF SUMMARY
FIELD OF THE INVENTION
The present invention relates to a method and case for disinfection of contact lenses wherein the contact lenses are placed in a hydrogen peroxide solution, in a case, and where neutralization of the cleaning fluid is carried out over a period of time by a NaCl tablet containing a neutralization agent catalyst, or the NaCl is slowly dissolved during the neutralization process.
BACKGROUND OF THE INVENTION
Users of contact lenses, particularly soft contact lenses, are familiar with the fact that contact lenses frequently, preferably daily, have to be cleaned to avoid inconveniences in the use of contact lenses.
Normally hydrogen peroxide is used for disinfection of contact lenses which are placed in special cases, which may be used for the storage of the contact lenses as well as for disinfection of the lenses. The contact lenses are kept in the cleaning fluid (hydrogen peroxide) until their next use, for example through the night.
In order to neutralize the hydrogen peroxide before next use of the contact lenses, it is known to neutralize the hydrogen peroxide with a "platinum star", which acts as a catalyst, or using an enzyme tablet containing, for example catalase, to neutralize the hydrogen peroxide.
U.S. Pat. No. 4,011,941 discloses an apparatus comprising a cleaning capsule for sterilizing soft contact lenses in an aqueous hydrogen peroxide solution and a method where the neutralizing agent is brought into contact with the cleaning solution by inverting the cleaning capsule--and where use is made of a catalytic reactor coated with a layer of platinum.
To ensure that there will be time enough for the hydrogen peroxide to disinfect the contact lenses from microorganisms and viruses before the neutralization, it is furthermore known to delay the effect of catalase using a special tablet, where the catalase is coated with methyl-cellulose or a PVP-film. EP-A-O 209 071 discloses the use of such an encapsulated neutralizing tablet which is inserted into the cleaning solution and releases the neutralizing agent with delay.
Catalase is an enzyme, which is capable of converting the hydrogen peroxide into water and free oxygen. In practice, the tablet used contains a salt with catalase, so that the hydrogen peroxide is converted into physiological salt water.
SUMMARY OF THE INVENTION
The purpose of the invention is to provide a method enabling a further improvement in disinfection of contact lenses.
The method according to the invention is distinctive in that disinfection of the contact lenses and neutralization of the cleaning fluid, respectively, are controlled by a tablet which is not coated and contains the enzyme catalase, said tablet is placed in a separate chamber or in a special position, and that the admission of a cleaning fluid to this chamber or this position is controlled by the generation of oxygen by the reaction between the cleaning fluid and the enzyme catalase.
In a simple manner it hereby becomes possible to control the duration of the disinfection as well as the neutralization of the cleaning fluid with a simple catalase tablet, which does not need any coating, that is a rather cheap catalase tablet may be used to control of a slowly, delayed neutralization of the cleaning fluid.
The invention furthermore relates to a case for use in carrying out the method according to the invention, which case is distinctive in that it comprises a chamber with a room for a right contact lens and a room for a left contact lens, and a chamber or a special position, which is adapted to receive a catalase tablet, said chambers are connected with each other in such a manner that the admission of the cleaning fluid to the neutralization agent is controlled.
Expediently, the case is provided with an opening between said chamber for the contact lenses and said chamber for the catalase tablet, said opening for free access of fluid is placed in a level just under the tablet in the chamber, the position of said opening is adapted to control the speed of the neutralization by controlling
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Naff David M.
Ware Deborah K.
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