Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...
Patent
1995-06-19
1998-12-15
Walsh, Stephen
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving antigen-antibody binding, specific binding protein...
530300, 530350, 530399, 436501, G01N 33566, C07K 1471, C07K 14475
Patent
active
058495010
ABSTRACT:
Novel TNF receptor death domain ("TNF-R1-DD") ligand proteins are disclosed. Polynucleotides encoding the TNF-R1-DD ligand protein are also disclosed, along with vectors, host cells, and methods of making the TNF-R1-DD ligand protein. Pharmaceutical compositions containing the TNF-R1-DD ligand protein, methods of treating inflammatory conditions, and methods of inhibiting TNF-R death domain binding are also disclosed. Methods of identifying inhibitors of TNF-R death domain binding and inhibitors identified by such methods are also disclosed.
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Chen Jennifer
Lin Lih-Ling
Schievella Andrea R.
Brown Scott A.
DesRosier Thomas J.
Genetics Institute Inc.
Kaufman Claire M.
Sprunger Suzanne A.
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