Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving nucleic acid
Patent
1997-05-16
1998-12-15
Patterson, Jr., Charles L.
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving nucleic acid
435196, 4352523, 4357201, 536 232, C12Q 168, C12N 916, C12N 1555
Patent
active
058494987
ABSTRACT:
The present invention provides a human 3-hydroxyisobutyryl-coenzyme A hydrolase (HIBCOH) and polynucleotides which identify and encode HIBCOH. The invention also provides expression vectors, host cells, and antibodies. The invention also provides methods for the prevention and treatment of diseases associated with expression of HIBCOH, as well as diagnostic assays.
REFERENCES:
Shimomura, Y. et al., "Purification and Partial Characterization of 3-Hydroxyisobutyryl-coenzyme A Hydrolase of Rat Liver", J. Biol. Chem., 269: 14248-14253 (1994).
Corkey, B.E. et al., "Regulation of the Branched Chain .alpha.-Ketoacid Pathway in Liver", J. Biol. Chem., 257: 9668-9676 (1982).
Brown, G.K. et al., ".beta.-Hydroxyisbutyryl Coenzyme A Deacylase Deficiency: A Defect in Valine Metabolism Associated with Physical Malformations", Pediatrics, 70: 532-538 (1982).
Hawes, J.W. et al., "Primary Structure and Tissue-specific Expression of Human .beta.-Hydroxyisobutyryl-coenzyme A Hydrolase", J. Biol. Chem., 271: 26430-26434 (1996).
Wilson, R. et al., "2.2 Mb of contiguous nucleotide sequence from chromosome III of C. elegans", Nature, 368: 32-38 (1994).
Wilson, R. et al., (Direct Submission), GenBank Sequence Database (Accession U00050), National Center for Biotechnology Information, National Library of Medicine, Bethesda, Maryland, 20894 (1994).
Bandman Olga
Corley Neil C.
Guegler Karl J.
Shah Purvi
Billings Lucy J.
Incyte Pharmaceuticals Inc.
Patterson Jr. Charles L.
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