Method for production of monoclonal antibodies in chimeric mice

Drug – bio-affecting and body treating compositions – Whole live micro-organism – cell – or virus containing – Genetically modified micro-organism – cell – or virus

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424 91, 435 702, 435 7021, 4351723, 435325, 435326, 435337, 5303871, 5303881, 53038815, 800 2, 935 89, A01N 5300, A61K 4900, C12N 500, C12N 516

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058492887

ABSTRACT:
Non-human chimeric mammals are created from a mammal having hematopoietic cells replaced with hematopoietic cells from a hematopoietic deficient mammal donor, and in which xenogeneic hematopoietic cells and/or tissue are engrafted. The chimeric mammal can produce xenogeneic, preferably human, B and/or T cells, and can be used as a source of mammalian, preferably human, monoclonal antibodies and/or T cells.

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