Bis-amide disulfide cleavable cross-linking reagents

Details Bis-amide disulfide cleavable cross-linking reagents Bis-amide disulfide cleavable cross-linking reagents

1983-11-14

1985-04-16

Kight, John

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

260121, 260117, 2604655R, 564209, C07G 700

Patent

active

045115010

ABSTRACT:
Cleavable cross-linking reagents having the general formula: ##STR1## wherein R and R.sub.1 are lower alkyl or lower alkenyl groups having one to four carbon atoms and X is a halide. A preferred example of the invention is represented by the formula: ##STR2## Compounds of the present invention are useful in establishing cleavable cross links between sulfhydryl groups of protein molecules.

REFERENCES:
patent: 3072707 (1963-01-01), Pierson et al.
patent: 3365480 (1968-01-01), Cobb, et al.
patent: 3595915 (1971-07-01), Emerson et al.
patent: 4101388 (1978-07-01), Rubinstein et al.
patent: 4179514 (1979-12-01), D'Silva
"Evidence of Inactivation of Pineal . . . Exchange", Namboodiri et al., JBC 255(13), Jul. 7, 1980, pp. 6032-6035.
Chem Abstract, No. 49013y, "Chemical and physicochemical properties of amino . . . disulfides, vol. 74, 1971, p. 507.
"N,N'-Bis(.alpha.-iodoacetyl)-2,2'-dithiobis (ethylamine), . . . Groups", Analytical Chem, 117, (1981), pp. 76-80, Luduena et al.
Double Agents, Bifunctional Cross-Linking Reagents.
"N,N-Bis(.alpha.-iodoacetyl)-2,2'-dithiobis(ethylamine), a Reversible CrossLinking Reagent for Protein Sulfhydryl Groups", Richard F. Luduena, et al., published Oct. 1981.
Reiner et al., J. Molecular Catalysis, 1:3-12, (1975).

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