Technetium-99M labeled peptides for thrombus imaging

Details Technetium-99M labeled peptides for thrombus imaging Technetium-99M labeled peptides for thrombus imaging

1994-07-11

1998-12-15

Kight, John

Drug, bio-affecting and body treating compositions

Radionuclide or intended radionuclide containing; adjuvant...

In an organic compound

534 10, 534 14, 424 9, 424 165, A61K 5100, A61M 3414

Patent

active

058492607

ABSTRACT:
This invention relates to radiolabeled peptides and methods for producing such peptides. Specifically, the invention relates to specific binding peptides, methods and kits for making such peptides, and methods for using such peptides labeled with technetium-99m via a radiolabel-binding moiety covalently linked to the peptide to image thrombus sites in a mammalian body.

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patent: 5508020 (1996-04-01), Dean et al.
Pearson et al (1996), J. Med. Chem. vol. 39, No. 7, pp. 1372-1382, Thrombus Imaging Using Technetium--99m Labeled High Potency GPII b/III a Receptor Antagonists.
Chemistry and Initial Biological Studies.
Fritzberg et al "Specific & Stable labeling of Antibodies with Technetium--99m with a diamide dithioate chelating agent" Proc. Natl. Acad. Sci. 85 pp. 4025-4029 (1988).
Knight, Sem. Nucl. Med. 20:52-67 (1990).
Knight, 1990, "Radiopharmaceuticals for Thrombus Detection", Sem. Nucl. Med. 20: 52-67.
Baidoo & Lever, 1990, "Synthesis of a Diaminedithiol Bifunctional Chelating Agent for Incorporation of Technetium--99m into Biomolecules", Bioconjugate Chem. 1:132-137.
Bryson et al., 1990, "Protecting Groups in the Preparation of Thiolate Complexes of Technetium", Inorganic Chem. 29: 2948-2951.

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