Azabicyclic intermediates for pharmaceutical compounds

Details Azabicyclic intermediates for pharmaceutical compounds Azabicyclic intermediates for pharmaceutical compounds

1983-02-25

1986-07-08

Rotman, Alan L.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

546112, 546133, 260239BF, 548515, C07D45114

Patent

active

045994200

ABSTRACT:
This invention relates to novel substituted benzamides having useful pharmacological properties, to pharmaceutical compositions containing them, to a process for their preparation and to intermediates therefor.
N-(2-Diethylaminoethyl)-2-methoxy-4-amino-5-chlorobenzamide, 1-ethyl-2(2-methoxy-5-sulphamoylbenzamidomethyl)pyrrolidine and N-[4'-(1"-benzyl)-piperidyl]-2-methoxy-4-amino-5-chlorobenzamide are well known compounds having useful pharmacological activity such as the ability to regulate the gastro-intestinal function anti-emetic activity and CNS activity.
It has now been found that certain intermediates for a structurally distinct class of substituted benzamides also has useful pharmacological activity, in particular dopamine antagonist activity.

REFERENCES:
March, Advanced Organic Chemistry: Reactions, Mechanisms and Structure, McGraw-Hill Pub., pp. 899-900, (1968).
P. A. S. Smith, The Chemistry of Open-Chain Organic Nitrogen Compounds, vol. I, Benjamin Pub., p. 65, (1965).
Chem. Abstracts, vol. 52(1), p. 1291-c-g, Jan. 10, 1958.

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