Drug – bio-affecting and body treating compositions – Anti-perspirants or perspiration deodorants
Patent
1998-03-19
1999-11-09
Dodson, Shelley A.
Drug, bio-affecting and body treating compositions
Anti-perspirants or perspiration deodorants
424 66, 424 67, 424 68, 424400, 424401, A61K 732, A61K 700
Patent
active
059808748
DESCRIPTION:
BRIEF SUMMARY
BACKGROUND OF THE INVENTION
Field of the Invention
This invention relates to translucent antiperspirants/deodorants based on fine-droplet sprayable microemulsions. The invention also relates to microemulsion concentrates and to a process for the production of translucent antiperspirants/deodorants from such concentrates. The stable microemulsions according to the invention essentially have a droplet diameter of less than 100 nm.
DESCRIPTION OF THE INVENTION
Prior Art
The use of oil-in-water emulsions as carriers for cosmetic and dermatological active substances has been known for some time. One difficulty is that the stability of the carrier system is often adversely affected by the nature of the active substances. It was already known from German patent application P 43 37 041.1 that very fine-droplet emulsions produced by the phase inversion process are particularly suitable as carriers for organic deodorants, perfume oils and sun protection factors. However, it could not be concluded from this document that such emulsions would also be suitable as carriers for water-soluble, inorganic, astringent antiperspiration agents.
The problem addressed by the invention was to improve the skin and mucous membrane compatibility of antiperspirants by using an emulsion of which the oil components have a softening and inflammation-inhibiting effect on the skin as carriers for the astringent agents. The particularly high compatibility would be achieved by using a fine-droplet emulsion as carrier for the antiperspiration agent. The problem with such fine-particle emulsions was above all that the usual oil-in-water emulsions were not sufficiently stable in the presence of the inorganic agents and that the viscosity of the microemulsions generally increased so drastically with decreasing droplet size that the microemulsions could no longer be processed in the form of a sprayable carrier.
It has now surprisingly been found that the problem stated above can be solved by using as the carrier a very fine-droplet emulsion such as can be obtained, for example, by using large quantities of suitable nonionic surfactants, optionally in conjunction with co-emulsifiers. The invention provides both translucent, fine-droplet and also low-viscosity and hence sprayable antiperspirants.
Substances acting as antiperspirants generally have a deodorizing effect as well so that, in the context of the present invention, antiperspirants also include compositions where for the most part the deodorizing effect is predominant. This can be the case, for example, with compositions which contain the antiperspiration agent in such low concentrations that the deodorizing component of the action spectrum predominates over the antiperspiration component. Accordingly, the term antiperspirants as used in the following is synonymous with antiperspirants/deodorants or antiperspirants and deodorants.
Accordingly, the present invention relates to translucent antiperspirants in the form of a sprayable, fine-droplet oil-in-water emulsion containing phase, from the group of alkyl polyglycosides, other typical additives, weight of an inorganic astringent antiperspiration agent and in that the droplet size of the emulsified phase is essentially between 10 and 100 nm.
The antiperspirant formulations according to the invention are distinguished by particularly high dermatological compatibility of the antiperspiration agent which they retain even in the event of regular use.
Suitable water-soluble, inorganic astringent antiperspiration agents are, above all, salts of aluminium, zirconium or zinc.
Examples of these suitable antihydrotic agents include aluminium chloride, aluminium chlorohydrate, aluminium dichlorohydrate, aluminium sesquichlorohydrate and complex compounds thereof with 1,2-propylene glycol, aluminium hydroxyallantoinate, aluminium chloride tartrate, aluminium/zirconium trichlorohydrate, aluminium/zirconium tetrachlorohydrate, aluminium/zirconium pentachlorohydrate and complex compounds thereof with amino acids, for example with glycine.
Howe
REFERENCES:
patent: 3547828 (1970-12-01), Mansfield et al.
patent: 5138046 (1992-08-01), Wuesr et al.
Emulsions: Theory and Practice 182-86 (1965).
J. Jpn. Oil Chem. Soc. (Yukagaku) 44(2):116-20 (1995) (Chem. Abstracts 122:191041j (1995)).
J. Pharm. Pharmacol. 27:385-96 (1975) (plus abstract).
Banowski Bernhard
Claas Marcus
Foerster Thomas
Dodson Shelley A.
Henkel Kommanditgesellschaft auf Aktien
J. Murphy Glenn E.
Jaeschke Wayne C.
Szoke Ernest G.
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