Chemistry: natural resins or derivatives; peptides or proteins; – Peptides of 3 to 100 amino acid residues
Patent
1996-01-17
1999-01-26
Marschel, Ardin H.
Chemistry: natural resins or derivatives; peptides or proteins;
Peptides of 3 to 100 amino acid residues
435 5, 435 6, 435 691, 436501, 514 2, 514 44, 530323, 530332, 536 221, 536 231, 536 241, 536 243, 536 2431, 536 2432, 536 2433, 536 253, 935 77, 935 78, C07K 400, C07K 700, C07K 704
Patent
active
058640100
ABSTRACT:
New sub-monomer synthetic methods for the preparation of peptide nucleic acid oligomeric structures are disclosed that provide for the synthesis of both predefined sequence peptide nucleic acid oligomers as well as random sequence peptide nucleic acid oligomers. Further these methods also provide for the incorporation of peptide nucleic acid units or strings of such units with amino acids or strings of amino acids in chimeric peptide nucleic acid-amino acid compounds. Further disclosed are method of making random libraries of peptide nucleic acids using the fully preformed monomers.
REFERENCES:
patent: 3803118 (1974-04-01), Bennett
Fukuda et al. (1994) Peptide Chemistry, 1993, pp. 45-48.
Egholm et al. (1992) Innovative Perspect. Solid Phase Synth. Collect. Pao. Int. Symposium (Ed. Upton, R., Andover, UK) pp. 325-328.
Garner, et al., "Peptide-Based Nucleic Acid Surrogates Incorporating Ser
Nielsen, et al., "Peptide Nucleic Acid (PNA). A DNA Mimic with a Peptide Backbone", Bioconjugate Chem., 5, 1994, pp. 3-7.
Geysen, et al., "Strategies for epitope analysis using peptide synthesis", J. Immunol. Meth., 102, 1987, 259-274.
Houghten, et al., "Generation and use of synthetic peptide combinatorial libraries for basic research and drug discovery", Nature, 354, 1991, 84-86.
Owens, et al., "The Rapid Identification of HIV Protease Inhibitors Through the Synthesis and Screening of Defined Peptide Mixtures", Biochem. and Biophys. Res. Commun., 181, No. 1, 1991, 402-408.
Wyatt, et al., "Combinatorially selected guanosine-quartet structure is a potent inhibitor of human immunodeficiency virus envelope-mediated cell fusion", Proc. Natl. Acad. Sci., 91, USA, 1994, 1356-1360.
Ecker, et al., "Rational screening of oligonucleotide combinatorial libraries for drug discovery", Nucleic Acids Research, 21, No. 8, 1993, 1853-1856.
Simon, et al., "Peptoids: A modular approach to drug discovery", Proc. Natl. Acad. Aci, USA, 89, 1992, 9367-9371.
Zuckermann, et al., "Efficient Method for the Preparation of Peptoids Am. Chem. Soc., 114, 1992, 10646-10647.
Ohlmeyer, et al., "Complex synthetic chemical libraries indexed with molecular tags" Proc. Natl. Acad. Sci. USA, 90, 1993, 10922-10926.
Patel, "Marriage of convenience", Nature, 365, 1993, 490-492.
Westhof, et al., "RNA pseudoknots", Current Opinion in Structural Biology, 2, 1992, 327-333.
Ecker, et al., "Pseudo-Half-Knot Formation with RNA", Science, 257, 1992, 958-961.
Dennis, "Phospholipases", The Enzymes, vol. XVI, 1983, 307-353.
Glaser, et al., "Phospholipase A.sub.2 enzymes: regulation and inhibition", TIPS Reviews, 14, 1993, 92-98.
Pruzanski, et al., "Enzymatic Activity and Immunoreactivity of Extracellular Phospholipase A.sub.2 in Inflammatory Synovial Fluids", Inflammation, 16, No. 5, 1992, 451-457.
Vishwanath, et al., "Edema-Inducing Activity of Phospholipase A.sub.2 Purified from Human Synovial Fluid and Inhibition by Aristolochic Acid", Inflammation, 12, No. 6, 1988, 549-561.
Bomalaski, et al., "Human Extracellular Recombinant Phospholipase A.sub.2 Induces an Inflammatory Response in Rabbit Joints", J. Immunol., 146, 1991, 3904-3910.
Scott, et al., "Interfacial Catalysis: The Mechanism of Phospholipase A.sub.2 ", Science, 250, 1990, 1541-1546.
Wery, et al., "Structure of recombinant human rheumatoid arthritic synovial fluid phospholipase A.sub.2 at 2.2A resolution", Nature, 352, 1991, 79-82.
Achari, et al., "Facing up to Membranes: Structure/Function Relationships in Phospholipases", Cold Spring Harbor Symp. Quant. Biol. 52, 1987, 441-452.
Cho, et al., "The Chemical Basis for Interfacial Activation of Monomeric Phospholipases A.sub.2 ", J. Biol. Chem., 263, No. 23, 1988, 11237-11241.
Yang, et al., "Studies on the status of Iysine residues in phospholipase A.sub.2 from Naja naja atra (Taiwan cobra) snake venom", J. Biochem., 262, 1989, 855-860.
Noel, et al., "Phospholipase A.sub.2 Engineering. 3. Replacement of Lysine-56 by Neutral Residues Improves Catalytic Potency Significantly, Alters Substrate Specificity, and Clarifies the Mechanism of Interfacial Recognition", J. Am. Chem. Soc., 112, 1990, 3704-3706.
Burack, et al., "Role of Lateral Phase Separation in the Modulation of Phospholipase A.sub.2 Activity", Biochemistry, 32, No. 2, 1993, 583-589.
Grainger, et al., "An enzyme caught in action: direct imaging of hydrolytic function and domain formation of phospholipase A.sub.2 in phosphatidylcholine monolayers", FEBS Lett., 252, No. 1, 2, 1989, 73-82.
Yuan, et al., "Synthesis and Evaluation of Phospholipid Analogues as Inhibitors of Cobra Venom Phospholipase A.sub.2 ", J. Am. Chem. Soc., 109, No. 26, 1987, 8071-8081.
Washburn, et al., "Suicide-inhibitory Bifunctionally Linked Substrates (SIBLINKS) as Phospholipase A.sub.2 Inhibitors", J. Biol. Chem., 266, No. 8, 1991, 5042-5048.
Campbell, et al., "Inhibition of Phospholipase A.sub.2 ; a Molecular Recognition Study", J. Chem. Soc., Chem. Commun., 1988, 1560-1562.
Davidson, et al., "1-Stearyl, 2-Stearoylaminodeoxy Phosphatidylcholine, A Potent Reversible Inhibitor of Phospholipase A.sub.2 ", Biochem. and Biophys. Res. Commun., 137, No. 2, 1986, 587-592.
Miyake, et al., "The Novel Natural Product 4-hydroxyphenyl)chroman!: A Competitive Inhibitor of Group II Phospholipase A.sub.2 ", J. Pharmacol. Exp. Ther., 263, 1992, 1302-1307.
Epton, et al., "Gel phase .sup.13 C n.m.r. spectroscopy as an analytical method in solid (gel) phase peptide synthesis", Polymer, 21, 1980, 1367-1371.
Stewart and Young, eds., "Solid Phase Peptide Synthesis", 2nd ed., 1984, p. 88.
Lombardo, et al., "Cobra Venom Phospholipase A.sub.2 Inhibition by Nanoalide", J. Biol. Chem., 260, No. 12, 1985, 7234-7240.
Ecker, et al., "PNA hybridizes to complementary oligonucleotides obeying the Watson-Crick hydrogen-bonding rules", Nature, 365, 1993, 566-568.
Egholm, et al., "Peptide Nucleic Acids (PNA), Oligonucleotide Analogues with an Achiral Peptide Backbone," J. Am. Chem. Soc. 114 (5):, 1992, 1895-1897.
Pischel, et al., "Synthesis and Biological Activity of N-Substituted 5-Fluorouracil-1-Acetammides," Collection of Czechoslovak Chemical Communications 47., 1982, 2806-2813.
Cook Phillip Dan
Kiely John
Sprankle Kelly
ISIS Pharmaceuticals Inc.
Marschel Ardin H.
LandOfFree
Peptide nucleic acid combinatorial libraries does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Peptide nucleic acid combinatorial libraries, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Peptide nucleic acid combinatorial libraries will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1451290