Use of bradykinin antagonists for the production of pharmaceutic

Details Use of bradykinin antagonists for the production of pharmaceutic Use of bradykinin antagonists for the production of pharmaceutic

1997-03-04

1999-01-26

Tsang, Cecilia J.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

514 16, 514893, 530327, 530328, 530314, A61K 3800

Patent

active

058639012

ABSTRACT:
This invention relates to a method of treating a chronic fibrogenetic liver disorder and/or an acute liver disorder and/or complications associated therewith, comprising administering to a patient a therapeutically effective amount of a bradykinin antagonist. Particular complications associated with said liver disorders include portal hypertension, decompensation phenomena such as ascites, edema formation, hepatorenal syndrome, hypertensive gastropathy and colopathy, splenomegaly and hemorrhagic complications in the gastrointestinal tract due to portal hypertension, collateral circulation and hyperemia and a cardiopathy as a result of a chronically hyperdynamic circulatory situation and its consequences.

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Schrier et al, Hepatology 8, pp. 1151-1157 (1988).
Madeddu et al, Br. J. Pharmacol. 106 pp. 380-386 (1992).
Majima et al, Hypertension, 22 pp. 705-714 (1993).

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