Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Recombinant dna technique included in method of making a...
Patent
1997-09-12
1999-01-26
Duffy, Patricia
Chemistry: molecular biology and microbiology
Micro-organism, tissue cell culture or enzyme using process...
Recombinant dna technique included in method of making a...
4351723, 435325, 4353201, 536 235, 536 2431, 536 2433, C07H 2104, C12N 1563, C12N 121, C12N 1585
Patent
active
058637664
ABSTRACT:
The invention provides a human sigma receptor (SIGR) and polynucleotides which identify and encode SIGR. The invention also provides expression vectors, host cells, agonists, antibodies and antagonists. The invention also provides methods for treating disorders associated with expression of SIGR.
REFERENCES:
Quirion, R. et al., "A proposal for the classification of sigma binding sites." TIPS (1992) 13:85-86.
Hanner, M. et al., "Purification, molecular cloning, and expression of the mammalian sigma.sub.1 -binding site." Proc.Natl.Acad.Sci.USA (1996) 93:8072-8077. (GI 1403300).
Monnet, F.P. et al., "The effects of sigma ligands and of neuropeptide Y on N-methyl-D-aspartate-induced neuronal activation of CA.sub.3 dorsal hippocampus neurones are differentlly affected by pertussin toxin." Br.J.Pharmacol. (1994) 112:709-715.
Su, T-P, "Putative links between nervous, endocrine and immune systems." Eur.J.Biochem. (1991) 200:633-642.
Hanner, M. et al. (GI 1403300), GenBank Sequence Database (Accession Z66537), National Center for Biotechnology Information, National Library of Medicine, Bethesda, Maryland, 20894, Oct. 7, 1996.
Hanner, M. et al. (GI1403299), GenBank Sequence Database (Accession Z66537), National Center for Biotechnology Information, National Library of Medicine, Bethesda, Maryland, 20894, Oct. 7, 1996.
Kekuda, R. et al (GI 1783387), GenBank Sequence Database (Accession U75283), National Center for Biotechnology Information, National Library of Medicine, Bethesda, Maryland, 20894, Mar. 25, 1997.
Kekuda, R. et al., "Cloning and functional expression of the human type 1 sigma receptor (hSigmaR1)." Biochem.Biophys.Res.Commun. (1996) 229:553-558.
Casellas, P. et al., (GI 1916800) GenBank Sequence Database (Accession U79528), National Center for Biotechnology Information, National Library of Medicine, Bethesda, Maryland, 20894, Dec. 5, 1996.
Corley Neil C.
Hillman Jennifer L.
Shah Purvi
Billings Lucy J.
Duffy Patricia
Incyte Pharmaceuticals Inc.
Price Leanne C.
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