Drug – bio-affecting and body treating compositions – Lymphokine
Patent
1990-10-15
1991-06-18
Russel, Jeffrey E.
Drug, bio-affecting and body treating compositions
Lymphokine
424 858, 530388, 530389, 530390, 530391, A61K 3944, C07K 1702
Patent
active
050248340
ABSTRACT:
Heterobifunctional crosslinkers up to about 34 .ANG. in length consisting of a sulfhydryl reactive group linked to a spacer group, which in turn is linked to an activated carboxylate group, that are useful for making efficacious anticancer immunotoxin conjugates as shown preferably by reacting an antibody associated amino group with the activated carboxylate group to form an antibody crosslinker complex and reacting the antibody crosslinker complex with a cytotoxin having a reactive sulfhydryl group with the sulfhydryl reactive group of the crosslinker, and using the conjugates so produced to treat cancer patients.
REFERENCES:
patent: 4762707 (1988-08-01), Jansen et al.
patent: 4943636 (1990-07-01), Nitecki et al.
patent: 4981979 (1991-01-01), Sivam
Blair et al. (1983) J. Immunol Methods 59, 129-143.
Ghose et al., (1983) Methods Enzymol 93: 280-333.
Vallera et al., (1983) Science 222: 512-515.
Aldwin Lois
Houston L. L.
Nitecki Danute E.
Cetus Corporation
Giotta Gregory J.
Halluin Albert P.
Kim Kay
Russel Jeffrey E.
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