5,7 Dihydroxy-1-(trimethoxybenzyl)-1,2,3,H-tetrahydroisoquinolin

Details 5,7 Dihydroxy-1-(trimethoxybenzyl)-1,2,3,H-tetrahydroisoquinolin 5,7 Dihydroxy-1-(trimethoxybenzyl)-1,2,3,H-tetrahydroisoquinolin

1975-10-30

1977-10-18

Daus, Donald G.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Bacterium or component thereof or substance produced by said...

260289D, A61K 3147, C07D21365

Patent

active

040546594

ABSTRACT:
A novel 5,7-dihydroxytetrahydroisoquinoline derivative having the formula: ##STR1## wherein R is trimethoxyphenyl, is prepared either by hydrolysis of a compound having the formula: ##STR2## wherein R.sup.1 is an organic acyl group and R is same as above, or by catalytic hydrogenation of a compound having the formula: ##STR3## wherein R.sup.3 is hydrogen or benzyl and R is same as above. The 5,7-dihydroxytetrahydroisoquinoline derivative (I) or a pharmaceutically acceptable acid addition salt thereof is useful as a bronchodilator.

REFERENCES:
patent: 3873704 (1975-03-01), Yamato et al.
patent: 3978063 (1977-03-01), Kishimoto et al.
Shamma "The Isoquinoline Alkaloids, Chem. and Pharmacology", pp. 79 & 212, Academic Press (1972).

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