Process for the resolution of pyrano[3,4-b]indole-1-acetic acids

Details Process for the resolution of pyrano[3,4-b]indole-1-acetic acids Process for the resolution of pyrano[3,4-b]indole-1-acetic acids

1984-02-16

1985-10-01

Daus, Donald G.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C07D49504

Patent

active

045447578

ABSTRACT:
Mixtures of racemic (.+-.)pyrano[3,4-b]indole-1-acetic acids are resolved with (-)-borneol to obtain the substantially pure (+) and (-)-enantiomers. The resolution involves the formation of a mixture of the diastereoisomeric pyrano[3,4-b]indole-1-acetic acid, (-)-borneol esters, separation of the diastereoisomeric esters, and hydrolysis of the latter esters.

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