Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...
Patent
1978-03-06
1985-10-01
Daus, Donald G.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Heterocyclic carbon compounds containing a hetero ring...
544 22, A61K 31545, C07D50124
Patent
active
045446539
ABSTRACT:
The present invention relates to a new syn-isomer of 3,7-disubstituted-3-cephem-4-carboxylic acid compounds and pharmaceutically acceptable salts thereof. More particularly, it relates to new syn-isomer of 3,7-disubstituted-3-cephem-4-carboxylic acid compounds and pharmaceutically acceptable salts thereof which have antibacterial activities and to processes for the preparation thereof, to pharmaceutical composition comprising the same, and to a method of using the same therapeutically in the treatment of infectious diseases in human beings and animals. New cephems disclosed herein are ##STR1## wherein R.sup.1 is ##STR2## R.sup.2 is lower alkyl, R.sup.3 is carboxy, R.sup.4 is carbamoyloxy methyl which may be substituted with a trihalo- (lower) alkanoyl; and R.sup.7 is amino, lower alkanoylamino or halo (lower)alkanoylamino.
REFERENCES:
patent: 3966717 (1976-06-01), Cook
patent: 3974153 (1976-08-01), Cook et al.
patent: 4098888 (1978-07-01), Ochiai et al.
Kochi Hiromu
Masugi Takashi
Takasugi Hisashi
Takaya Takao
Benson Robert
Daus Donald G.
Fujisawa Pharmaceutical Co. Ltd.
Stemple Dayton R.
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