Method of producing acyclovir

Details Method of producing acyclovir Method of producing acyclovir

1982-10-14

1985-10-01

Tanenholtz, Alvin E.

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Preparing heterocyclic carbon compound having only o, n, s,...

514261, 514934, C12P 1718, A01N 4390, A61K 3152

Patent

active

045446342

ABSTRACT:
The novel compound 6-deoxyacyclovir is enzymatically converted to acyclovir by xanthine oxidase/dehydrogenase or aldehyde oxidase in vivo, i.e. within the body of the animal being treated. The enzymatic conversion may also be effected ex vivo (i.e. in vitro) as a method of synthesizing acyclovir.

REFERENCES:
Krenitsky et al., Archive of Biochemistry and Biophysics, vol. 185, No. 2, pp. 370-375, Jan. 30, 1978; vol. 150, No. 2, pp. 585-599, Jun. 1972.

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