Interferon-gamma receptor fragment and its production

Details Interferon-gamma receptor fragment and its production Interferon-gamma receptor fragment and its production

1990-09-07

1993-06-22

Russel, Jeffrey E.

Chemistry: natural resins or derivatives; peptides or proteins;

Proteins, i.e., more than 100 amino acid residues

530351, 530413, 530416, 530834, C07K 302, C07K 320, C07K 322

Patent

active

052217892

ABSTRACT:
Soluble human IFN-gamma receptor extracellular fragment and salts, functional derivatives, precursors and active fractions thereof are provided in substantially purified form. They are useful as pharmaceutically active substances for protecting against the deleterious effects of IFN-gamma, e.g. in autoimmune diseases.

REFERENCES:
patent: 4485017 (1984-11-01), Tan et al.
patent: 4897264 (1990-01-01), Novick et al.
Novick et al. J. Chromatography, vol. 510, pp. 331-337, Jun. 1990.
Novick et al. J. Exp. Med., vol. 170 No. 4, pp. 1409-1414, Oct. 1989.
Aguet, et al.; Cell, 55:273-280 (1988); Molecular Cloning and Expression of the Human Interferon-Receptor.

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