Preparation of 2-hydroxyphenyl-acetic acid

Details Preparation of 2-hydroxyphenyl-acetic acid Preparation of 2-hydroxyphenyl-acetic acid

1991-06-04

1993-06-22

Killos, Paul J.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carboxylic acids and salts thereof

C07C 6501

Patent

active

052217728

ABSTRACT:
A process for the preparation of: ##STR1## the process comprising treating (2-chlorophenyl)acetic acid with an alkali metal hydroxide (for example, sodium hydroxide) in an organic solvent (for example, an inert hydrocarbon solvent), in the presence of a catalyst (for example a copper salt) at a temperature above 130.degree. C. (for example in the range 130.degree. C. to 300.degree. C.).

REFERENCES:
Noller C. R. "Chem of Organic Cmpds" W. B. Saunders Company Oct. 1960 p. 510.
Chem. Ber. (1920), 53, p. 2230.
Chem. Ber (1905), 38, pp. 2121-2126.
J. Am. Chem. Soc., vol. 45, pp. 1906-1916.
J. Chem. Soc., (1929), pp. 1870-1873 (Chem. Abs., vol. 24 p. 77).
J. Chem. Soc. (1927), pp. 113-1122.
Zh. Org. Khim (1971), vol. 7, part 12, pp. 2567-2569 (Chem. Abs. 76 72171Y).

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