Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1991-04-24
1993-06-22
Rizzo, Nicholas S.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
5483365, 548109, 514338, 514399, C07D23364, A61K 31415
Patent
active
052216888
ABSTRACT:
The invention relates to salts formed between basic H.sub.2 -receptor antagonists and a complex of zinc with a carboxylic acid selected from tartaric acid, citric acid and alkyl citric acids, and to solvates of such salts, excluding salts in which the basic H.sub.2 -receptor antagonist is ranitidine. Examples of basic H.sub.2 -receptor antagonists are cimetidine, famotidine, nizatidine and roxatidine.
The salts are useful in the treatment of gastrointestinal disorders, such as peptic ulcer disease and non-ulcer dyspepsia.
REFERENCES:
patent: 4956466 (1990-09-01), Vinas
patent: 4965365 (1990-10-01), Sanfeliu et al.
patent: 5008256 (1991-04-01), Clitherow
Cho, Drug Development Research, 17:185-197 (1989).
Escolar et al., Drugs Exptl. Clin. Res., XV(2) 83-89 (1989).
Clitherow John W.
Collington Eric W.
Glaxo Group Limited
Rizzo Nicholas S.
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