Process for preparing 5H-pyrrolo[2,1-c]-[1,4]thiazepine-1,5-dion

Details Process for preparing 5H-pyrrolo[2,1-c]-[1,4]thiazepine-1,5-dion Process for preparing 5H-pyrrolo[2,1-c]-[1,4]thiazepine-1,5-dion

1982-05-10

1983-07-05

Bond, Robert T.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

2602393T, 548540, 548492, C07D51304

Patent

active

043917526

ABSTRACT:
The invention relates to the preparation of 1-bromo-2-D-alkylpropanoyl-L-proline derivatives and analogous compounds which are useful as chemical intermediates to angiotensin converting enzyme (ACE) inhibitors and to the stereospecific synthesis of such ACE inhibitors having the formula: ##STR1## wherein R.sup.1 is lower alkyl and R.sup.4 and R.sup.5 are both hydrogen or together with the carbons to which they are attached represent a benzene ring optionally substituted by defined substituents. Intermediates of formula ##STR2## are also disclosed wherein R.sup.1, R.sup.4, R.sup.5 are as defined above and B.sup.30 is a cation.

REFERENCES:
patent: 4105776 (1978-08-01), Ondetti et al.
patent: 4192945 (1980-03-01), Ondetti
March, Advanced Org. Chem. Reactions, Mechanisms and Structure, p. 81, McGraw-Hill Book Co., (1968).

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