Pharmaceutical composition for injection

Details Pharmaceutical composition for injection Pharmaceutical composition for injection

1984-11-02

1986-04-15

Meyers, Albert T.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514973, A61K 31415

Patent

active

045828458

ABSTRACT:
A pharmaceutical composition is provided herein containing as a key ingredient 4-carbamoyl-imidazolium-5-oleate of the formula (I) ##STR1## its salt or hydrate thereof, and one or more of a sulfur compound capable of producing at least one of the ions selected from HSO.sub.3.sup.--, SO.sub.3.sup.2-- and S.sub.2 O.sub.5.sup.2--. The sulfur compounds prevent discoloration of the composition.
The stabilization against coloration is further enhanced by the presence of L-cysteine hydrochloride. The solubility of the compound (I) can be further enhanced by the presence of a basic substance. The active ingredient is known as a therapeutic agent for the treatment of such diseases as rheumatism and nephritis.

REFERENCES:
patent: 4181731 (1980-01-01), Yoshida et al.
Miller et al., J.A.M. Chem. Soc. 74:2892-41952.

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