Antibiotic A80190, pharmaceutical compositions containing same a

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Carbohydrate doai

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536 168, 536 181, A61K 3170, C07H 1704

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active

045828229

ABSTRACT:
New polyether antibiotic A80190, its acyl and alkyl ester, acyl ester and urethane derivatives, and salts thereof, are useful antibacterial and anticoccidial agents and increase feed-utilization efficiency in animals. Methods of making A80190 by culture of Actinomodura oligospora NRRL 15877 and synergistic compositions of the A80190 compounds with nicarbazin, 4,4'-dinitrocarbanilide, certain napthalenamine and benzenamine compounds and metichlorpindol are also provided.

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J. Tone et al., "CP-47, 433 and CP-47,434, New Polycyclic Ether Antibiotics Produced by a New Species of Actinomadura," in Current Chemotherapy and Infectious Disease, J. D. Nelson and C. Grassi, Eds., vol. I, American Society for Microbiology, Washington, D.C. 1980, pp. 469-470.
Nakamura et al., "A New Species of Actinomadura Producing a Polyether Antibiotic, Cationomycin," J. Antibiotics 36, 1468-1472 (1983).
Derwent Abstract No. 83-834403/49 of European Patent 95-154-A to Fujisawa Pharm. KK.
"Polyether Antibiotics, Naturally Occurring Acid Ionophores, vol. 1, Biology", J. W. Westley, Ed., Marcel Dekker Inc., New York, 1982, pp. viii-xi.
"Polyether Antibiotics: Naturally Occurring Acid Ionophores", vol. 2, Chemistry J. W. Westley Ed., Marcel Dekker, Inc., New York 1983, p. 197 and excerpts from pp. 223-224.

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