Process for imaging cardiac infarcts

Details Process for imaging cardiac infarcts Process for imaging cardiac infarcts

1983-09-19

1986-04-15

Nucker, Christine M.

Drug, bio-affecting and body treating compositions

Radionuclide or intended radionuclide containing; adjuvant...

2605025E, 424 9, 562499, A61K 4300, A61K 4900

Patent

active

045826986

ABSTRACT:
The imaging of cardiac infarcts with complexed radioactive metals is improved by employing as the complexing agent a compound of the formula ##STR1## wherein substituents A, B, X and Y are each independently selected from radicals including hydrogen, hydroxyalkyl (wherein the alkyl group contains 2-6 carbon atoms), methylenephosphonic, methylene-, ethylene-, and propylenesulfonic, carboxylic acid radicals (having 2-4 carbon atoms) and the alkali or alkaline earth metal, ammonia and amine salts thereof and wherein at least one A, B, X and Y is methylenephosphonic acid or a salt thereof. In particular Tc-99m complexes have been found useful for imaging damaged cardiac tissue.

REFERENCES:
patent: 3983227 (1976-09-01), Tofe et al.
patent: 4036945 (1977-07-01), Haber
patent: 4234562 (1980-11-01), Tofe et al.
patent: 4385046 (1983-05-01), Milbrath et al.
patent: 4387087 (1983-06-01), Deutsch et al.
"Heart Imaging with Cationic Complexes of Technetium", Science, 214, 85-86 (1981).
"Infarct Sizing in Awake, Unsedated Dogs with Acute Anterior Myocardial Infarcts", Journal of Nuclear Medicine, 17, (6), 534 (1976).
"Uptake of Tc-99m Pyrophosphate (PYP) and Calcium (Ca) in Irreversibly Damaged Myocardium", Ibid.
"Uptake of Six Techneitum-99m Radiopharmaceuticals and Strontium-85 in Vasopressin-Induced Rabbit Myocardial Infarction", Ibid, 534-535.
"A New Method for Radionuclide Imaging of Myocardial Infarcts", Radiology, 110, 473 (1974).
"Radiopharmaceuticals in Cardiovascular Nuclear Medicine", Seminars in Nuclear Medicine, vol. IX, No. 4, 241-256 (1979).
"Tc-99m HMDP (Hydroxymethylene Diphosphonate): A Radiopharmaceutical for Skeletal and Acute Myocardial Infarct Imaging", Journal of Nuclear Medicine, vol. 21, No. 10, 961-966 (1980).

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