Phenyl-lower-alkylamines

Details Phenyl-lower-alkylamines Phenyl-lower-alkylamines

1975-12-22

1977-02-15

Hines, Robert V.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

260348R, 2605011, 26050111, 2605012, 26050121, 260558R, 260592, 260599, 424316, 424330, C07C 9128

Patent

active

040082768

ABSTRACT:
Phenyl-lower-alkylamines having anti-inflammatory activity are prepared either by reductive alkylation of an amine with a phenyl-lower-alkanaldehyde; by condensation of a phenyl-lower-alkanaldehyde with a secondary amine, conversion of the resulting phenylvinylamine to the corresponding iminium salt, and reduction of the latter with an alkali metal borohydride; or by reaction of a phenyl-lower-alkanoyl halide with an amine and reduction of the resulting amide with a reagent effective to reduce an amide to an amine.

REFERENCES:
patent: 3126381 (1964-03-01), Lanzis et al.
Stavrovskaya et al., "Chemical Abstracts", vol. 50, p. 1765 (1956).
Damiens, "Chemical Abstracts", vol. 47, pp. 2695-2696 (1953).

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