Preparation of 4-amino-6-(pyridinyl)-3(2H)-pyridazinones from 6-

Details Preparation of 4-amino-6-(pyridinyl)-3(2H)-pyridazinones from 6- Preparation of 4-amino-6-(pyridinyl)-3(2H)-pyridazinones from 6-

1981-03-02

1982-08-24

Berch, Mark L.

Organic compounds -- part of the class 532-570 series

Organic compounds

Four or more ring nitrogens in the bicyclo ring system

544239, C07D40104, A61K 3150

Patent

active

043462219

ABSTRACT:
4-Amino-2-R-6-PY-3(2H)-pyridazinones (I) or salts thereof, which are useful as cardiotonics, where R is hydrogen, lower-alkyl or lower-hydroxyalkyl, and PY is 4- or 3-pyridinyl or 4- or 3-pyridinyl having one or two lower-alkyl substituents are prepared by: (a) reaction of 2-R-6-PY-3(2H)-pyridazinone (II) with hydrazine; (b) conversion from 2,3-dihydro-2-R-3-oxo-6-PY-4-pyridazinecarboxamide (III); or, (c) conversion form 2,3-dihydro-2-R-3-oxo-6-PY-4-pyridazinecarboxylic acid hydrazide (IV). Also shown are: the use of I or salts as cardiotonic agents; and, the preparation of intermediates.

REFERENCES:
Glushkov et al., Chem. Abs. 79, 125894g (1973).
Cheeseman et al., Chem Abs. 74, 112014s (1971).

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